数字农科院2.0

NIR/pH-responsive arginine-ε-polylysine/black phosphorus nanocomposites for synergistic therapy of bacterial infections

文献类型： 外文期刊

作者： Qian Gao;Ranran Fu;Mengting Li;Dongbo Guo;Bingcheng Gan;Tao Wang;Maohua Chen

作者机构：

关键词： Black phosphorus nanosheets;Nitric oxide gas therapy;Photodynamic therapy;Synergistic antibacterial effect;ε-Polylysine

期刊名称： Materials Today Bio

ISSN： 2590-0064

年卷期： 2025 年 34 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The escalating global burden of drug-resistant bacterial infections demands urgent innovation in highly effective, non-invasive antimicrobial strategies. Herein, we developed a multimodal near infrared (NIR) light-responsive bactericidal nanoplatform (BP@EPL-LA) with surface charge adaptability by loading black phosphorus nanosheets with L-Arg-grafted ε-poly(L-lysine) for targeted combinatorial therapy of subcutaneous abscesses. Under physiological conditions, BP@EPL-LA remained a neutral surface charge and demonstrated excellent biosafety both in vitro and in vivo. Upon encountering the acidic infectious environment, BP@EPL-LA rapidly switched to a positive surface charge, promoting deep biofilm penetration and strong electrostatic adhesion to negatively charged bacterial membranes. When irradiated by 660 nm laser, BP@EPL-LA mediated antibacterial photodynamic therapy (aPDT), generating reactive oxygen species (ROS) that oxidized arginine residues to enable controlled nitric oxide (NO) release. BP@EPL-LA effectively dispersed bacterial biofilms and demonstrated broad-spectrum antibacterial activity through the synergistic combination of ROS, NO, and EPL. Moreover, BP@EPL-LA showed remarkable therapeutic outcomes in a mouse model of subcutaneous Methicillin-resistant Staphylococcus aureus abscesses, simultaneously eradicating bacterial infection, reducing inflammation, and promoting tissue healing via enhanced vascularization and collagen deposition. Therefore, BP@EPL-LA overcomes antibiotic resistance barriers and presents a promising therapeutic strategy for effective subcutaneous abscess treatment by integrating NO-potentiated aPDT with EPL's bactericidal action.

分类号：

  • 相关文献

[1]A High-Sensitivity Thermal Analysis Immunochromatographic S.ensor Based On Au N anoparticle-Enhanced Two-Dimensional Black Phosphorus Photothermal-Sensing Materials. Wang, Junying,Wang, Shuo,Sheng, Wei,Li, Shijie,Wang, Junping,Wen, Wenjun,Zhang, Ying. 2019

[2]Sequential growth of sandwiched NaYF4:Yb/Er@NaYF4:Yb@NaNdF4:Yb core-shell-shell nanoparticles for photodynamic therapy. Peng, Huang-Yong,Ding, Bin-Bin,Ma, Yin-Chu,Tao, Wei,Yang, Xian-Zhu,Qian, Hai-Sheng,Sun, Shi-Qi,Guo, Hui-Chen,Sun, Shi-Qi,Guo, Hui-Chen,Guo, Yan-Chuan.

[3]Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy. Chen, Cong,Wang, Jianmin,Li, Xiaoyan,Chen, Cong,Wang, Jianmin,Li, Xiaoyan,Liu, Xiaolong,Liu, Xiaolong,Han, Xiao.

[4]Antimicrobial And Anticancer Applications And Related Mechanisms Of Curcumin-Mediated Photodynamic Treatments. Yang, QQ, Farha, AK, Kim, G, Gul, K, Gan, RY, Corke, H. 2020

[5]Facile One-Pot Assembly of a Versatile Photoactive Nanozyme for Highly Efficient Antibacterial Therapy. Chen, Yingying,Ma, Kang,Liang, Meijuan,Dong, Pei,Wang, Hong,Yu, Shanshan,Sun, Jianwei,Kwok, Ryan T. K.,Lam, Jacky W. Y.,Gao, Yuhui,Tang, Ben Zhong,Wang, Fuan. 2025

作者其他论文 更多>>