数字农科院2.0

The bZIP transcription factor RISBZ1 balances grain filling and ER stress response in rice grains

文献类型： 外文期刊

作者： Qi Sun;Erchao Duan;Ruonan Jing;Yulong Ren;Huan Xu;Chuanwei Gu;Wenting Lv;Xiaokang Jiang;Rongbo Chen;Qingkai Wang;Yipeng Zhang;Rushuang Zhang;Hongyi Xu;Yunpeng Zhang;Jiajia Chi;Yunfei Fu;Yun Zhu;Yu Zhang;Binglei Zhang;Xuan Teng;Hui Dong;Xue Yang;Lei Zhou;Yunlu Tian;Xi Liu;Shijia Liu;Xiuping Guo;Cailin Lei;Ling Jiang;Yihua Wang;Jianmin Wan

作者机构：

关键词： bZIP50;bZIP60;endosperm development;RISBZ1;unfolded protein response

期刊名称： Plant Communications

ISSN： 2590-3462

年卷期： 2025 年 6 卷 9 期

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度）

摘要： In cereal crops, the endosperm synthesizes large quantities of proteins, including storage proteins and functional factors essential for the accumulation of storage reserves. The unfolded protein response (UPR) monitors the folding of nascent polypeptides in the endoplasmic reticulum (ER) to alleviate cellular stress. However, the molecular mechanisms linking the UPR to endosperm development in plants remain poorly understood. In this study, we isolated and characterized a rice (Oryza sativa L.) mutant with defective endosperm development, designated as floury endosperm27 (flo27). Molecular cloning revealed that FLO27 encodes RISBZ1/bZIP58, an endosperm-specific transcription factor co-expressed with seed storage protein (SSP) genes and starch biosynthesis-related genes in rice. The flo27 mutant exhibited severe ER stress, along with upregulation of UPR-related genes. Notably, RISBZ1 interacts with bZIP50 and bZIP60 to antagonistically suppress downstream UPR genes. These interactions simultaneously downregulate SSP and starch biosynthesis-related genes, ultimately leading to reduced dry matter accumulation. In conclusion, these findings demonstrate that RISBZ1 functions as a “brake signal” to mitigate ER stress, thus enhancing our understanding of the trade-off between grain filling and adaptation to adverse environmental conditions in rice.

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