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The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth

文献类型： 外文期刊

作者： Chenrui Wang;Song Cao;Chen Shi;Mengbo Guo;Dongdong Sun;Zheyi Liu;Peng Xiu;Yong Wang;Guirong Wang;Yang Liu

作者机构：

关键词： （2-2-2）Helicoverpa armigera;Molecular docking;Olfactory sensilla;Pheromone receptor;Type II sex pheromone

期刊名称： Cellular and Molecular Life Sciences

ISSN： 1420-682X

年卷期： 2024 年 81 卷 1 期

页码：

收录情况： SCIE（2024版）

摘要： Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on Helicoverpa armigera, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones—3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H—in H. armigera. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.

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