数字农科院2.0

Selenomethionine Regulates the Arachidonic Acid Metabolism-Ferroptosis-Inflammation Axis to Ameliorate Colitis

文献类型： 外文期刊

作者： Tian, Huihui;Zhou, Longzhu;Feng, Xiaohui;Shen, Jialu;Du, Xiaoping;Zhao, Qingyu;Qin, Yuchang;Zhang, Junmin;Tang, Chaohua

作者机构：

关键词： arachidonic acid metabolism;colitis;ferroptosis;gut microbiota;inflammation;oxylipin;selenomethionine

期刊名称： ANIMAL RESEARCH AND ONE HEALTH

ISSN： 2835-5075

年卷期： 2026 年

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收录情况： 无来源刊（2025版）

摘要： Selenium (Se) is an essential trace element with multiple biological functions, including anti-inflammatory, antioxidant, growth-regulating, and immunomodulatory functions. Dysregulation of the arachidonic acid (AA) metabolism-ferroptosis-inflammation axis is associated with the progression of intestinal inflammatory diseases, suggesting that its nutritional regulation holds potential for health management. This study explored how selenomethionine (Se-Met), a bioactive dietary form of Se, regulates this axis to promote gut health using a murine model of AA-induced colitis. C57BL/6J mice were pre-fed a diet with Se-Met (0.2 or 1.0 mg/kg) for 6 weeks, followed by intragastric administration of AA (30 mg/day) for 4 weeks. The results showed that excessive AA intake induced colitis, characterized by intestinal inflammation and barrier dysfunction. Se-Met supplementation alleviated colitis symptoms, improved intestinal barrier function, and inhibited inflammation. Mechanistically, Se-Met enhanced antioxidant defenses by upregulating selenoprotein expression, modulated AA metabolism to reduce the production of pro-inflammatory oxylipins, and inhibited the ferroptosis signaling pathway. Transcriptomics analysis revealed systemic regulatory effects of Se-Met on pathways related to inflammation and lipid metabolism, whereas 16S rRNA sequencing showed that Se-Met remodeled the gut microbiota. These findings highlight that Se-Met alleviates colitis through multi-targeted regulation of the AA metabolism-ferroptosis-inflammation axis, thereby providing experimental support for dietary Se supplementation in gut health protection and informing nutritional strategies for managing inflammatory bowel disease.

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