数字农科院2.0

Dietary Flavonoid Quercetin Supplement Promotes Antiviral Innate Responses Against Vesicular Stomatitis Virus Infection by Reshaping the Bacteriome and Host Metabolome in Mice

文献类型： 外文期刊

作者： Li, Tingting;Zhu, Jinfeng;Yu, Qifeng;Zhu, Yinrui;Wu, Chao;Zheng, Xing;Chen, Nannan;Pei, Pei;Yang, Kai;Wang, Kai;Hu, Lin

作者机构：

关键词： gut microbiota;metabolomics;pro-inflammatory cytokines;quercetin;vesicular stomatitis virus

期刊名称： MOLECULAR NUTRITION & FOOD RESEARCH

ISSN： 1613-4125

年卷期： 2024 年

页码：

收录情况： SCIE（2024版）

摘要： ScopeActive ingredients in functional foods exhibit broad-spectrum antiviral activity. The objective of this study is to investigate the protective effect of quercetin derived from bee propolis, a natural product with antiviral activity and modulating effects on the gut microbiota, against vesicular stomatitis virus (VSV) infection.Methods and resultsThrough a cellular-based study, this study demonstrates that quercetin can modulate the activity of interferon-regulating factor 3 (IRF3). In vivo, it shows that quercetin protects mice from VSV infection by enhancing interferon production and inhibiting the production of proinflammatory cytokines. The study conducts 16S rRNA-based gut microbiota and nontargets metabolomics analyses to elucidate the mechanisms underlying quercetin-mediated bidirectional communication between the gut microbiome and host metabolome during viral infection. Quercetin not only ameliorates VSV-induced dysbiosis of the intestinal flora but also alters serum metabolites related to lipid metabolism. Cross-correlations between the gut bacteriome and the serum metabolome indicate that quercetin can modulate phosphatidylcholine (16:0/0:0) and 5-acetylamino-6-formylamino-3-methyluracil to prevent VSV infection.ConclusionThis study systematically elucidates the anti-VSV mechanism of quercetin through gut bacteriome and host metabolome assays, offering new insights into VSV treatment and revealing the mechanisms behind a novel disease management strategy using dietary flavonoid supplements. In a study using vesicular stomatitis virus (VSV) as a model, this study evaluates six propolis-derived flavonoids: quercetin, kaempferol, galangin, pinocembrin, apigenin, and chrysin. Quercetin activates the host's innate immunity by modulating gut microbiota and metabolism, promoting interferon production, and suppressing proinflammatory cytokines, effectively protecting mice from VSV infection. image

分类号：

  • 相关文献

[1]Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis. Yanan Lv,Jing Peng,Xiaoyu Ma,Zeyi Liang,Ghasem Hosseini Salekdeh,Qunhua Ke,Wenxiang Shen,Zuoting Yan,Hongsheng Li,Shengyi Wang,Xuezhi Ding. 2024

[2]Gut microbiota-driven regulation of queen bee ovarian metabolism. Li, Wan-Li,Huang, Qi,Li, Jia-Li,Wu, Ping,Wei, Bangrong,Li, Xi-Jie,Tang, Qi-He,Dong, Zhi-Xiang,Xiong, Jian,Tang, Hong,Zhang, Jun,Zhao, Chong-Hui,Cao, Zhe,Chen, Yuan,Zhao, Wen-zheng,Wang, Kai,Guo, Jun. 2023

[3]Impact of Clarified Apple Juices with Different Processing Methods on Gut Microbiota and Metabolomics of Rats. Lei Xu,Shini Yang,Kewen Wang,Anjing Lu,Xue Wang,Zhenzhen Xu. 2022

[4]Systems Biology Approaches for Understanding Metabolic Differences Using 'Multi-Omics' Profiling of Metabolites in Mice Fed with Honey and Mixed Sugars. Zheng, Xing,Zhao, Yazhou,Naumovski, Nenad,Zhao, Wen,Yang, Guan,Xue, Xiaofeng,Wu, Liming,Granato, Daniel,Peng, Wenjun,Wang, Kai. 2022

[5]Saccharomyces boulardii protects against murine experimental colitis by reshaping the gut microbiome and its metabolic profile. Hui Gao,Yinzheng Li,Jiqu Xu,Xuezhi Zuo,Tiantian Yue,Huzi Xu,Jie Sun,Meng Wang,Ting Ye,Yan Yu,Ying Yao. 2023

[6]Nodakenin Ameliorates Ovariectomy-Induced Bone Loss by Regulating Gut Microbiota. Chunxiao Liu,Jingyue Chen,Zijiao Wang,Yueyao Li,Yuanyuan Zhang,Guangyu Li. 2024

[7]Queen Bee Larva, an Edible By-Product of Royal Jelly, Alleviate D-Galactose-Induced Aging in Mouse by Regulating Gut Microbiota Structure and Amino Acid Metabolism. Tong Zhao,Xiaofeng Xue,Pingxiang Liu,Han Hu,Kai Wang,Yutao Wang,Liming Wu. 2024

[8]Utilizing Lactic Acid Bacteria to Improve Hyperlipidemia: A Comprehensive Analysis from Gut Microbiota to Metabolic Pathways. Changlu Ma,Chen Xu,Mumin Zheng,Shuwen Zhang,Qifeng Liu,Jiaping Lyu,Xiaoyang Pang,Yinghong Wang. 2024

[9]Early-Life Galacto-Oligosaccharide Supplementation Induces Persistent Immunoglobulin and Metabolic Alterations in Holstein Dairy Calves by Shaping Gut Microbiota. Huang, Qi,Chang, Meinan,Sun, Peng. 2026

[10]Gut microbiota regulates the brain metabolism of sexually mature drones. Zhang, Jun,Zhao, Ya-Zhou,Hou, Meng-Shang,Tang, Qi-He,Pang, Yan-Tao,Li, Xi-Jie,Xiong, Jian,Zhao, Chong-Hui,Huang, Qi,Tian, Shao-Jiang,Dong, Zhi-Xiang,Liu, Zhen-Xing,Guo, Jun. 2025

[11]PLC-gamma 1 is involved in the inflammatory response induced by influenza A virus H1N1 infection. Xu, Shuai,Yang, Jiayun,Zhu, Qiyun,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Liang, Yuying.

[12]Inflammatory response and insulin signaling alteration induced by PCB77. Wang, Jing,Du, Yuguo,Lv, Xiaowen.

[13]Anti-inflammatory activities of phospholipase C inhibitor U73122: Inhibition of monocyte-to-macrophage transformation and LPS-induced pro-inflammatory cytokine expression. Zhu, Qiyun,Zhu, Liqian,Yuan, Chen,Ma, Yan,Ding, Xiuyan,Zhu, Guoqiang,Zhu, Liqian,Yuan, Chen,Ma, Yan,Ding, Xiuyan,Zhu, Guoqiang.

[14]The effect of asparagine-13 in porcine epidemic diarrhea virus envelope protein on pathogenicity. Li, Zhiwei,Ma, Zhiqian,Zhao, Xiaojing,Li, Yongqi,Zheng, Congsen,Li, Yang,Guo, Xuyang,Xu, Lele,Zheng, Zifang,Zheng, Haixue,Xiao, Shuqi. 2025

[15]Expression analyses and antiviral properties of the Beijing-You and White Leghorn myxovirus resistance gene with different amino acids at position 631. Du, L. X.,Zhao, G. P.,Zhang, C. S..

[16]Protective efficacy of a recombinant Newcastle disease virus expressing glycoprotein of vesicular stomatitis virus in mice. Zhang, Minmin,Ge, Jinying,Li, Xiaofang,Chen, Weiye,Wang, Xijun,Wen, Zhiyuan,Bu, Zhigao. 2016

[17]Antiviral activity of doxycycline against vesicular stomatitis virus in vitro. Wu, Zhuan-chang,Wei, Jian-chao,Li, Bei-bei,Shao, Dong-hua,Li, Yu-ming,Liu, Ke,Shi, Yuan-yuan,Qiu, Ya-feng,Ma, Zhi-yong,Wang, Xin,Zhou, Bin. 2015

[18]The Multiplicity of Infection of Recombinant Vaccinia Virus Expressing the T7 RNA Polymerase Determines the Rescue Efficiency of Vesicular Stomatitis Virus. Yang F.,Tan J.,Fang Y.,Chen G.,Zhang Y.,Hu Q.,Han W.,Liu Y.,Fu B.,Jing Z.,Li W.. 2022

[19]Transcriptome analysis of long non-coding RNA and mRNA Profiles in VSV-infected BHK-21 Cells. Wuweiyi Han,Xiaojuan Fei,Fan Yang,Xintong Sun,Jianshe Yang,Jinxin Qiu,Luhua Zhang,Wenhui Zhang,Guohua Chen,Wei Han,Xiaobo He,Yongsheng Liu,Weike Li. 2024

[20]The Pseudotyped Replication-Deficient VSV with Spike from PEDV Induces Neutralizing Antibody Against PEDV. Jingxuan Yi,Huaye Luo,Kang Zhang,Lilei Lv,Siqi Li,Yifeng Jiang,Yanjun Zhou,Zuzhang Wei,Changlong Liu. 2025

作者其他论文 更多>>