数字农科院2.0

Preparation and characterization of a novel controlled-release nano-delivery system loaded with pyraclostrobin via high-pressure homogenization

文献类型： 外文期刊

作者： 王安琪;;崔建霞;;王琰;;朱华新;;李柠君;;王春鑫;;申越;;刘鹏飞;;崔博;;孙长娇;;赵翔;;王崇;;高飞;;曾章华;;崔海信

关键词： pyraclostrobin nanospheres; high-pressure homogenization; emulsion–solvent evaporation methods; controlled

期刊名称： PEST MANAGEMENT SCIENCE

ISSN： 1526-498X

年卷期： 2020 年 76 卷 0 期

页码：

收录情况： JCR（2021版）

摘要： BACKGROUND: The development of efficient and safe green pesticides is a scientific strategy to alleviate current pesticide residues, environmental pollution, and threats to non-target organisms. Pesticide controlled-release formulations (CRFs) have attracted wide attention because they can control the rate of release of active ingredients and prolong the effective duration. In particular, nanoscale pesticide sustained-release systems have excellent biological activity and distribution performance because of their small particle size. Some technical difficulties remain in obtaining nanoscale CRFs. RESULTS: We successfully fabricated pyraclostrobin nanosphere CRF by combining high-pressure homogenization technology and emulsion–solvent evaporation methods. The pyraclostrobin nanospheres had a uniform spherical shape with a mean particle size of 450 nm and polydispersity index of less than 0.3. The pyraclostrobin loading capacity reached 53.6%, with excellent storage stability. The contact angle of nanospheres on cucumber leaf surfaces demonstrated that it had good wettability. Compared with pyraclostrobin technical and commercial formulations, the nanosphere systems showed a significantly sustained release of pyraclostrobin for longer (up to 250 h). A preliminary bioassay against Penicillium ochrochloron showed that the bioactivity and long-term efficiency of pyraclostrobin nanospheres were superior to those of the commercial formulation. CONCLUSION: This research introduced a simple, fast, expandable method for preparing pyraclostrobin nanospheres. The results showed that pyraclostrobin nanospheres could prolong the duration of pesticide efficacy and enhance bioactivity. Furthermore, this technology provides a platform for scale-up production of nano-scale pesticide CRFs

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