数字农科院2.0

Homo-harringtonine (HHT) is highly effective against SARS-CoV-2

文献类型： 外文期刊

作者： 文海军;;;;Hua-Juan Ma;;;;钟功勋;;;;Ao Ding;;;;Xi Wang;;;;Xiao-Ju Lai;;;;Chang-Hao Shi;;;;Miles Tracy;;;;Si-Jin Wu;;;;Jia-Sheng Li;;;;Ge Zhang;;;;Yong- Bo Yao;;;;Wei Chen;;;;Xue- Yu Liu;;;;Zhi-Chao Xu;;;;Xue Cao;;;;Wen-Bin He;;;;Jing Feng;;;;Guo-Dong Wang;;;;Feng-Liang Liu;;;;Wei-Shun Zeng;;;;Guang-An Lu;;;;Jia- Yu Guo;;;;Yong-Tang Zheng;;;;Hui Zeng;;;;Xiong-Lei He;;;;Fu-Jie Zhang;;;;Zhi-Hong Hu;;;;Xue-Mei Lyu;;;;陈化兰;;;;Jian Li;;;;Man-Li Wang;;;;Qi-Chun Cai;;;;Chung-I Wu

期刊名称： National Science Review

ISSN： 2095-5138

年卷期： 2024 年

页码：

收录情况： SCIE（2024版） ; ; EI（2024版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2024版）

摘要： As COVID-19 is the third coronavirus epidemic in this century, it would be desirable to have a treatment scheme in anticipation of a fourth one. We here present a scheme that could clear SARS-CoV-2 in 2-4 days post infection from the upper respiratory tract (URT), where the virions are initially concentrated. The scheme, applicable in large scale by nasal spray, is based on Homo-harringtonine (HHT) that has been approved for treating other diseases. HHT blocked protein elongation and repressed in vitro replication of all 4 coronaviruses (including SARS-CoV-2) tested at the nano-molar concentration, demonstrating its potential of broad effectiveness against coronaviruses. In animal models, HHT cleared SARS-CoV-2 in all treated mice in 3 days by daily nasal dripping of a small dose (40 ug). In December 2022, HHT was administered to 26 cancer patients by nebulization at 1 mg/day. On average, the viral load in the URT was reduced by 3/4 six hours after the nebulization. In the wavelet of May 2023, 11 patients without other medical conditions were administered HHT by repeated liquid nasal spray at the low, total daily-dose of 0.2 mg. Ten of the 11 patients were cleared of the virus in 2-4 days. In comparison, in large-cohort studies of participants in China during the same wave, most patients need 7-9 to turn negative. No adverse effects were detected in any patient in the two clinical trials. A short review of drugs approved for treating COVID-19 shows the many advantages of HHT. With continual development, it could become a first-line defense at the onset of future coronavirus epidemics.

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