数字农科院2.0

Combined effects of microplastics and flupyradifurone on gut microbiota and oxidative status of honeybees (Apis mellifera L.)

文献类型： 外文期刊

作者： Tong An;Wangjiang Feng;Han Li;Yanyan Wu;Pingli Dai;Yong Jun Liu

作者机构：

关键词： Flupyradifurone;Gut microbiota;Honeybee;Microplastics;Oxidative status

期刊名称： Environmental Research

ISSN： 0013-9351

年卷期： 2025 年 270 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The increasing accumulation of polystyrene microplastics (PS-MPs) and the widespread use of flupyradifurone (FPF) affect honeybee health adversely. However, the combined impact of PS-MPs and FPF toxicity on honeybees remains unknown. In this study, honeybee (Apis mellifera L.) was fed with sucrose solutions containing PS-MPs (0.5 or 5 μm, 50 mg/L), FPF (4 mg/L), or their combination for 21 days under laboratory conditions. The effects of PS-MPs and FPF on honeybee physiology, gut microbiota, and stress-related enzyme activities and genes were measured. The findings showed that concurrent exposure to PS-MPs and FPF significantly reduced honeybee survival, with additive effects, decreased sucrose consumption and body weight, and devastated midgut epithelial cells. FPF was the main stressor affecting survival, while PS-MPs exerted a greater influence on body weight. Co-exposure to PS-MPs (0.5 μm) and FPF disrupted gut microbiota, significantly decreasing Lactobacillus abundance. Supplementation with Lactobacillus helsingborgensis improved honeybee survival, highlighting the protective role of gut microbiota. PS-MPs exposure, alone or combined with FPF, increased oxidative stress and decreased detoxification and immune capabilities in honeybees. These findings suggested the combined toxicity of PS-MPs and FPF on honeybees, underscoring the potential ecology risk posed by multiple stressors.

分类号：

  • 相关文献

[1]Polystyrene microplastics reduce honeybee survival by disrupting gut microbiota and metabolism. Han Li,Wangjiang Feng,Tong An,Pingli Dai,Yong Jun Liu. 2025

[2]Host species and geography differentiate honeybee gut bacterial communities by changing the relative contribution of community assembly processes. Yuan Ge,Zhongwang Jing,Qingyun Diao,Ji Zheng He,Yong Jun Liu. 2021

[3]Acaricide flumethrin-induced sublethal risks in honeybees are associated with gut symbiotic bacterium Gilliamella apicola through microbe-host metabolic interactions. Qi S.,Al Naggar Y.,Li J.,Liu Z.,Xue X.,Wu L.,El-Seedi H.R.,Wang K.. 2022

[4]Toxic effects of acaricide fenazaquin on development, hemolymph metabolome, and gut microbiome of honeybee (Apis mellifera) larvae. Jiangli Wu,Fengying Liu,Jiajing Sun,Qiaohong Wei,Weipeng Kang,Feng Wang,Chenhuan Zhang,Meijiao Zhao,Shufa Xu,Bin Han. 2024

[5]The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi. Shang, Xiaofei,Wang, Dongsheng,Miao, Xiaolou,Wang, Xuezhi,Li, Jianxi,Yang, Zhiqiang,Pan, Hu,Shang, Xiaofei,Wang, Dongsheng,Miao, Xiaolou,Wang, Xuezhi,Li, Jianxi,Yang, Zhiqiang,Pan, Hu. 2014

[6]Simultaneous determination of flupyradifurone and its two metabolites in fruits, vegetables, and grains by a modified quick, easy, cheap, effective, rugged, and safe method using ultra high performance liquid chromatography with tandem mass spectrometry. Liu, Xingang,Wu, Xiaohu,Dong, Fengshou,Xu, Jun,Zheng, Yongquan.

[7]Exposure to flupyradifurone affect health of biocontrol parasitoid Binodoxys communis (Hymenoptera: Braconidae) via disrupting detoxification metabolism and lipid synthesis. Gao X.,Zhao L.,Zhu X.,Wang L.,Zhang K.,Li D.,Ji J.,Niu L.,Luo J.,Cui J.. 2023

[8]Acute oral toxicity, apoptosis, and immune response in nurse bees (Apis mellifera) induced by flupyradifurone. Jing Gao,Yi Guo,Jin Chen,Qing Yun Diao,Qiang Wang,Ping Li Dai,Li Zhang,Wen Min Li,Yan Yan Wu. 2023

[9]Prediction of Potential Risk for Flupyradifurone and Its Transformation Products to Hydrobionts. Shen, Chao,Pan, Xinglu,Wu, Xiaohu,Xu, Jun,Zheng, Yongquan,Dong, Fengshou. 2024

[10]Multiple stresses induced by chronic exposure to flupyradifurone affect honey bee physiological states. Jin Chen,Yong Jun Liu,Qiang Wang,Li Zhang,Sa Yang,Wang Jiang Feng,Min Shi,Jing Gao,Ping Li Dai,Yan Yan Wu. 2024

[11]Differential antennal proteome comparison of adult honeybee drone, worker and queen (Apis mellifera L.). Fang, Yu,Song, Feifei,Zhang, Lan,Aleku, Dereje Woltedji,Han, Bin,Feng, Mao,Li, Jianke.

[12]Quantitative Neuropeptidome Analysis Reveals Neuropeptides Are Correlated with Social Behavior Regulation of the Honeybee Workers. Han, Bin,Fang, Yu,Feng, Mao,Hu, Han,Qi, Yuping,Huo, Xinmei,Meng, Lifeng,Wu, Bin,Li, Jianke.

[13]Proteome Analysis of Hemolymph Changes during the Larval to Pupal Development Stages of Honeybee Workers (Apis mellifera ligustica). Woltedji, Dereje,Fang, Yu,Han, Bin,Feng, Mao,Li, Rongli,Lu, Xiaoshan,Li, Jianke. 2013

[14]Western honeybee drones and workers (Apis mellifera ligustica) have different olfactory mechanisms than eastern honeybees (Apis cerana cerana). Woltedji, Dereje,Song, Feifei,Zhang, Lan,Gala, Alemayehu,Han, Bin,Feng, Mao,Fang, Yu,Li, Jianke.

[15]Changes of proteome and phosphoproteome trigger embryo-larva transition of honeybee worker (Apis mellifera ligustica). Gala, Alemayehu,Fang, Yu,Woltedji, Dereje,Zhang, Lan,Han, Bin,Feng, Mao,Li, Jianke.

[16]Managed honeybee colony losses of the Eastern honeybee (Apis cerana) in China (2011-2014). Chen, Chao,Liu, Zhiguang,Chen, Xiao,Guo, Haikun,Wang, Huihua,Tang, Jiao,Shi, Wei,Chen, Chao,Liu, Zhiguang,Shi, Wei,Luo, Yuexiong,Xu, Zheng,Wang, Shunhai,Zhang, Xuewen,Dai, Rongguo,Gao, Jinglin.

[17]Novel aspects of understanding molecular working mechanisms of salivary glands of worker honeybees (Apis mellifera) investigated by proteomics and phosphoproteomics. Feng, Mao,Fang, Yu,Han, Bin,Zhang, Lan,Lu, Xiaoshan,Li, Jianke.

[18]Proteome Comparison of Hypopharyngeal Gland Development between Italian and Royal Jelly-Producing Worker Honeybees (Apis mellifera L). Li Jianke,Feng Mao,Begna, Desalegn,Fang Yu,Zheng Aijuan. 2010

[19]Proteome Analysis Unravels Mechanism Underling the Embryogenesis of the Honeybee Drone and Its Divergence with the Worker (Apis mellifera lingustica). Fang, Yu,Feng, Mao,Han, Bin,Qi, Yuping,Hu, Han,Fan, Pei,Huo, Xinmei,Meng, Lifeng,Li, Jianke.

[20]Brain Membrane Proteome and Phosphoproteome Reveal Molecular Basis Associating with Nursing and Foraging Behaviors of Honeybee Workers. Han, Bin,Fang, Yu,Feng, Mao,Hu, Han,Hao, Yue,Ma, Chuan,Huo, Xinmei,Meng, Lifeng,Zhang, Xufeng,Wu, Fan,Li, Jianke.

作者其他论文 更多>>