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Intervention timing and disease stage shape tecovirimat and cidofovir efficacy in male SCID mice

文献类型： 外文期刊

作者： Xinyu Cao;Ning Shi;Xiangshu Qiu;Jiaxin Tian;Peng Wang;Bocheng Liu;Zhuo Ha;He Zhang;Chao Shang;Xiao Li;Yubiao Xie;Yuelong Shu;Huijun Lu

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期刊名称： Nature Communications

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年卷期： 2025 年 17 卷 1 期

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收录情况： SCIE（2025版） ; ; Nature Index（2023版）

摘要： Currently, mpox virus (MPXV) continues to pose a global public health challenge, with immunocompromised individuals often exhibiting more severe clinical symptoms. This study screens three male mouse models (ICR, IFNAR1-/-, SCID) and identifies SCID mice as the optimal model for modeling severe patient symptoms, including pneumonia, rash, and localized inflammation, which is applied to evaluate the antiviral efficacy of tecovirimat and cidofovir. Both drugs prevent systemic MPXV spread when administered within two days post virus exposure. Local antiviral efficacy differs between the two drugs, particularly after intradermal infection. Prolonged treatment up to 28 days post infection results in 100% survival of SCID mice but fails to effectively suppress localized rash and inflammatory swelling, suggesting that the drugs have limited impact at later stages of the disease. These findings indicate that the therapeutic efficacy of tecovirimat and cidofovir depends on the timing of intervention initiation and the stage of disease progression.

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