数字农科院2.0

Multi-Tissue Genetic Regulation of RNA Editing in Pigs

文献类型： 外文期刊

作者： Pan, Xiangchun;Gong, Wentao;Cai, Xiaodian;Teng, Jinyan;Cai, Jiali;Zeng, Haonan;Ayalew, Wondossen;Shen, Qingpeng;Zhong, Zhanming;Wang, Yifei;Zhang, Wenjing;Tian, Yuhan;Xu, Dantong;Gao, Yahui;Yin, Hongwei;Zhang, Yuebo;Hou, Jiahui;Zhou, Tianru;Li, Jiaqi;Fang, Lingzhao;Yuan, Xiaolong;Zhang, Zhe

作者机构：

关键词： PigGTEx;RNA editing;RNA editing quantitative trait loci;RNA-seq;SNP

期刊名称： ADVANCED SCIENCE

ISSN：

年卷期： 2026 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： RNA editing introduces transcriptomic variation and may contribute to complex trait regulation. However, its genetic determination in pigs remains unclear. Here, using 5457 PigGTEx RNA-seq samples across 34 porcine tissues, we construct a comprehensive RNA editome and map 49 614 cis-editing quantitative trait loci (edQTLs). These edQTLs define a distinct regulatory layer, with over 32% acting independently of expression or splicing QTLs (eQTLs/sQTLs). Crucially, edQTLs are significantly enriched in GWAS loci for 33 complex traits and show a superior contribution to heritability over eQTLs/sQTLs in some traits like growth and reproduction. Colocalization analyses pinpoint diverse causal mechanisms, revealing both edQTL-specific effects (e.g., ERCC5) and coordinated events where single variants pleiotropically modulate RNA editing, splicing, and gene expression. Human-pig comparative analysis identifies hundreds of evolutionarily conserved editing events linked to fundamental neurological pathways. This study provides the first comprehensive multi-tissue porcine RNA editome and edQTL map, establishing RNA editing as a key mechanism linking genetic variation to phenotypic diversity in a major agricultural species and offering a valuable resource for future functional genomics research.

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