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Targeting MAPK10 with gga-miR-222b-5p suppresses apoptosis in DF-1 cells infected with the avian reticuloendotheliosis virus strain SNV(REV-SNV)

文献类型： 外文期刊

作者： Qing Zhang;Yubo Zhao;Saisai Zhao;Xinhong Man;Shumin Yu;Youxiang Diao;Yi Tang;Jingdong Hu

作者机构：

关键词： Apoptosis;Cell cycle;Gga-miR-222b-5p;MAPK10;REV-SNV

期刊名称： Veterinary Microbiology

ISSN： 1873-2542

年卷期： 2025 年 310 卷

页码：

收录情况： SCIE（2025版）

摘要： Reticuloendotheliosis virus (REV), a retrovirus, causes reticuloendotheliosis in poultry, leading to severe immunosuppression. Evidence suggests that miR-222b-5p and mitogen-activated protein kinase 10 (MAPK10) exhibit tissue-specific differential expression patterns in the primary immune organs of specific pathogen–free chickens infected with the REV-SNV. In this study, we investigated the mechanisms underlying REV infection–induced changes in gga-miR-222b-5p and MAPK10 expression patterns. DF-1 cells were transfected with microRNA mimics or inhibitors to enable assessment of apoptosis, cell cycle progression, and cell viability, along with the differential expression patterns of gga-miR-222b-5p and MAPK10 in REV-infected cells. The results reveal that REV infection upregulated and downregulated miR-222b-5p and MAPK10, respectively, in a time- and dose-dependent manner. Overexpression of miR-222b-5p suppressed MAPK10 expression, thereby inhibiting apoptosis, enhancing cell viability, and accelerating cell cycle progression. These findings suggest that miR-222b-5p plays a vital role in REV infection–induced tumorigenesis.

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