数字农科院2.0

Next-Generation Vaccines for Co-Circulating PEDV and TGEV: Integrating Nucleic Acid Platforms, Mucosal Delivery, and AI–Driven Antigen Design

文献类型： 外文期刊

作者： Xiaojun Hu;Zhenshan Wang;Shen Wang;Hongyu Sun;Na Feng;Entao Li;Xianzhu Xia;Guixue Hu;Feihu Yan

作者机构：

关键词： AI–assisted antigen design;mucosal immunity;PEDV;TGEV;vaccine

期刊名称： Transboundary and Emerging Diseases

ISSN： 1865-1674

年卷期： 2025 年 2025 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are causative agents of acute enteric diseases in pigs and have a high contagion potential. These coronaviruses (CoVs) impose substantial economic losses on global pork production, particularly affecting lactating piglets where coinfections occur. Although traditional vaccines offer partial protection, their efficacy is increasingly challenged by the continuous emergence of mutated strains of PEDV and TGEV. This underscores the demand for novel vaccines with improved protective efficacy and cost-effectiveness. Emerging vaccine technologies, such as nucleic acid vaccines, genetically engineered subunit vaccines, and live vector vaccines, have received widespread attention because of their advantages in terms of safety, stability, targeted delivery, economy, and ease of use. This review summarizes recent advances in PEDV and TGEV vaccine development, highlighting both their potential and limitations. More importantly, we prospect novel techniques that may supplement the status gaps and lead to breakthroughs in blocking the transmission of these CoVs. Notable research priorities encompass mucosal immunity mechanisms, vertical transmission prevention strategies, and computational immunogen design leveraging artificial intelligence (AI). Overall, a deeper understanding of the pathogens coupled with technological advances is expected to accelerate the control of and effective response to pathogenic CoVs, thereby safeguarding the stability of animal husbandry.

分类号：

  • 相关文献

[1]2013-2014年全国23个地区猪腹泻病毒的流行病学调查. 张贺伟,张华,孟庆森,夏铭崎,王鑫,王炜,宋妮,宁晨,赵建增,武华. 2015

[2]A sensitive duplex nanoparticle-assisted PCR assay for identifying porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus from clinical specimens. Zhu, Yu,Wang, Chunren,Cui, Yudong,Cui, Shangjin,Zhu, Yu,Liang, Lin,Luo, Yakun,Cui, Shangjin,Wang, Guihua,Ai, Xia.

[3]Generation of a mouse scFv library specific for porcine aminopeptidase N using the T7 phage display system. Sun, Dongbo,Shi, Hongyan,Chen, Jianfei,Shi, Da,Liu, Shengwang,Wang, Yunfeng,Qiu, Huaji,Feng, Li,Sun, Dongbo,Zhu, Qinghe,Zhang, Hong.

[4]Different Infectivity of Swine Enteric Coronaviruses in Cells of Various Species. Li Z.,Chen Y.,Li L.,Xue M.,Feng L.. 2024

[5]Surface Display of Cholera Toxin B Subunit Recombinant Escherichia coli Ghosts Further Enhances Resistance to Chlamydia abortus Infection in Mice. Huaiyu Zhang,Yunhui Li,Wei Li,Zhaocai Li,Jizhang Zhou,Dewen Tong. 2024

[6]A novel recombination porcine epidemic diarrhea virus isolated from Gansu, China: Genetic characterization and pathogenicity. Li L.,Li B.,Wang J.,Liu L.,Li Y.,Sun S.,Yin S.,Zhang L.,Liu X.,Xu X.,Guo H.. 2024

[7]猪传染性胃肠炎病毒重组N蛋白抗原间接ELISA抗体检测方法的建立. 孙东波,冯力,时洪艳,刘胜旺,陈洪岩,佟有恩,李伟杰,王明,马思奇,陈建飞. 2006

[8]pAPN基因敲除的IPEC-J2介导的TGEV感染特征分析. 夏振涛,王楠,王婉洁,周期律,黄雷,牟玉莲. 2024

[9]马流感灭活疫苗的研制. 郭巍,戚亭,相文华,王晓钧. 2015

[10]Cloning and Functional Analysis of the Full Length cDNA Sequence of Eukaryotic Translation Initiation Factor 5 in Schistosoma japonicum. Cheng Guofeng,Lin Jiaojiao,Sun Jun,Li Hao,Zhu Chuangang,Zhou Yuancong,Cai Youmin. 2005

[11]ProtectiveimmunityinducedbyaDNAvaccineexpressingeIF4AofToxoplasmagondiiagainstacutetoxoplasmosisinmice. 陈佳,SiyangHuang,ZhongyuanLi,ZiguoYuan,DonghuiZhou,EskildPetersen,NianzhangZhang,XingquanZhu. 2013

[12]传染性法氏囊病病毒反向遗传技术发展及其应用DevelopmentandApplicationoftheReverseGeneticTechnologiesforInfectiousBursalDiseaseVirus. 祁小乐1,王永强1,高立1,高宏雷1,高玉龙1,王笑梅1,2*QIXiaole1,WANGYongqiang1,GAOLi1,GAOHonglei1,GAOYulong1,WANGXiaomei1,2*. 2015

[13]运用反向遗传学培养产生高成长性的猪流感疫苗(英文). TaoYangMingLiuChunguoLiuYunZhangDafeiLiuHaoChenBiotechnologyAnimalInfluenzaLaboratoryoftheMinistryAgricultureandNationalKeyLaboratoryofVeterinary,HarbinVeterinaryResearchInstituteofCAAS,Harbin150001,China. 2007

[14]表达H3N8亚型马流感病毒重组禽痘病毒载体疫苗的研究. 戚亭,郭巍,王晓钧. 2015

[15]猪流行性腹泻病毒感染猪小肠上皮细胞miRNA表达谱分析及验证. 张宸语,陈佳宁,温建新,刘光亮. 2018

[16]中国猪病毒性腹泻流行概况及其科学防控. 冯力,陈建飞,时洪艳,张鑫. 2015

[17]猪流行性腹泻病毒感染小肠上皮细胞后诱导的天然免疫应答. 刘平黄,符芳,潘巧,应兰,陈建飞,冯力. 2014

[18]病毒宏基因组学分析腹泻仔猪肠道病毒群落及变异PEDV的分离和鉴定. 单同领,童光志. 2013

[19]猪流行性腹泻病毒IgA抗体间接ELISA方法的建立. 刘烨,张家林,王潇博,石达,时洪艳,陈建飞,张鑫,冯力. 2019

[20]STAT3在猪流行性腹泻病毒感染的作用及机制初步探索. 杨丽君,张健,许嘉宇,张璐,冯力,陈洪岩,王玉娥. 2019

作者其他论文 更多>>