数字农科院2.0

Risks and underling mechanisms of sulfoxaflor exposure in honey bees (Apis mellifera): Physiology and behavior impairment

文献类型： 外文期刊

作者： Ding, Mu;Wang, Xue;Zhang, Wei;Huang, Aidi;Zhao, Wenting;Luo, Mai;Wu, Liming;Qi, Suzhen

作者机构：

关键词： Sulfoxaflor;Honeybees;Behavioral disorder;Gut toxicity;Metabolic disturbance

期刊名称： PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

ISSN： 0048-3575

年卷期： 2025 年 217 卷

页码：

收录情况： SCIE（2025版）

摘要： As the most widely used pesticides, the adverse effects of neonicotinoid insecticides to honeybees have been proven. This study assessed the exposure risks of Sulfoxaflor (Sul), an alternative of traditional neonicotinoids, to honey bee (Apis mellifera) workers and clarified its mechanism through gut microbiota and metabolomics analysis. The results revealed a high acute toxicity of Sul to bees with a 48-LD50 of 239 ng/bee via oral exposure. Chronic exposure to sublethal concentrations of Sul (1, 10, and 100 mu g/L) over 10 days significantly decreased the sucrose responsiveness, olfactory sensitivity, and COQ respiration rates of honeybees. Furthermore, sublethal exposure to Sul elicited distinct immunomodulatory, detoxification, and antioxidation responses in the midgut, as well as metabolic dysregulation. However, no substantial alterations in gut microbial composition or alpha/beta diversity was identified. These findings suggest that sublethal concentrations of Sul do not affect bee survival in a short time, however, they do induce multifaceted sublethal effects and disrupt intestinal physiology and metabolic homeostasis. Consequently, these effects pose ecological risks to honey bees. It is imperative that future research should comprehensively consider various exposure risks of insecticides, prioritize the identification of novel biomarkers to delineate their adverse mechanisms in organisms, particularly pollinating insects.

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