The p15 protein is a promising immunogen for developing protective immunity against African swine fever virus.
文献类型： 外文期刊
作者： 于琪;;付望君;;王祥喜;;赵东明
关键词： P15蛋白;;保护免疫;;非洲猪瘟病毒
期刊名称： Protein & Cell
ISSN： 1674-800X
年卷期： 2025 年
页码：
收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）
摘要： In summary, we identified a high-affinity and p15- specific neutralizing antibody 4E2 and analyzed the structure of its complex with p15 trimer. The structure of the p15-4E2 antibody complex unveils the precise nature of the epitope of p15, providing a powerful tool to elucidate the biological properties of p15 and aiding in the design of effective ASF vaccines. We successfully generated two types of p15-VLPs and found that repeated immunization with p15 or p15-VLPs provides effective immune protection against moderately virulent virus, with all immunized pigs surviving and showing reduced viral loads in their blood and tissue samples. However, a single use of p15 would likely not be sufficient to induce sufficient immune protection against highly virulent strains. Our data indicate that p15 is a critical viral protein essential for targeting to disrupt the viral life cycle. However, ASFV encodes more than 150 viral proteins, and successfully combating infections from highly virulent strains likely demands a coordinated immune response against multiple critical viral proteins, including those indirectly involved in aiding the virus in subverting or evading immune responses (Sunwoo et al., 2019). Therefore, there is an urgent need to screen for and identify more ASFV proteins like p15 that assist the virus infection, and characterize their epitopes, laying the foundation for the development of new ASF vaccines.
分类号：
- 相关文献
作者其他论文 更多>>
-
Regional projections and sampling strategies for the global germplasm resources collection of Oryza rufipogon Griff.
作者：王恺;;龙金花;;雷济舟;;梁云涛;;钱前;;郑晓明
关键词：Oryza rufipogon Griff.; Germplasm resource collection; Genetic diversity; Environmental factor; MaxEnt model
-
High-density cultivation of synthetic apomictic hybrid rice achieves near-complete 1 diploidization and parental-equivalent yield in field trials 2 Mengqiu Song1,5, Shengnan Li1,5, Zuan Wang1,5, Guojun Dong2 , Tao Wang1 , Jingxi Sun1 ,
作者：宋梦秋;;李胜男;;王钻;;董国军;;王涛;;孙景熙;;夏思琪;;杨泽园;;刘伟哲;;彭友林;;樊龙江;;孙健;;张勇;;王克剑;;郑晓明;;钱前
关键词：cultivation;;hybrid rice;;near-complete ;;diploidization;;parental-equivalent
-
Genome-wide identification of the Medicago ruthenica FTIP gene family and expression profiling under salt stresses
作者：田永雷;;朱琳;; 郭茂伟;;李志勇;; 武自念;;李鸿言;; 李星月;;王晓龙
关键词：FT-interacting proteins; Medicago ruthenica; genome-wide identification; salt stress; saline–alkali stress
-
Deciphering the ceRNA Network in Alfalfa: Insights into Cold Stress Tolerance Mechanisms
作者：朱琳;;赵宇杰;;郭茂伟;;白杰;;张良斌;;李志勇
关键词：alfalfa; cold stress; mRNAS; ncRNAs; ceRNAs
-
The threshold of aeration intensity in micro-oxygen lactic acid fermentation and the underlying microbial mechanisms
作者：曹起涛;;尹福斌;;连天境;;周谈龙;;蔡阳扬;;魏晓曼;;孙佳欣;;董红敏
关键词：agricultural waste; lactic acid; micro-oxygen; aeration threshold; microbial function
-
Strengthening global rice germplasm sharing: insights from the International Network for the Genetic Evaluation of Rice (INGER) platform
作者：樊佳雨;;夏思琪;;杨泽园;;郑晓明;;陈帆
关键词：ice germplasm resources · INGER · Sharing mechanism · Sustainable agricultural development
-
Contrasting effects of three aging processes on arsenic immobilization in red versus black soils amended by cerium-manganese modified biochar: the unique role of freeze-thaw cycling in governing arsenic fate at micro/nano interfaces
作者：吕鹏;;黄晓雅;;李莲芳*;;焦艳
关键词：Modifed biochar; Aging mechanism; Arsenic fate; Freeze–thaw cycling; Soil micro-interfaces