数字农科院2.0

Pexophagy-driven redox imbalance promotes virus-induced ferroptosis

文献类型： 外文期刊

作者： Hui Jiang;Yang Qu;Xianjin Kan;Mengqing Yang;Yabin Gong;Ying Liao;Xusheng Qiu;Lei Tan;Cuiping Song;Venugopal Nair;Chan Ding;Yingjie Sun

作者机构：

关键词： CP: Immunology;CP: Microbiology;ferroptosis;peroxisome;PEX5;pexophagy;ROS;virus

期刊名称： Cell Reports

ISSN： 2211-1247

年卷期： 2025 年 44 卷 6 期

页码：

收录情况： SCIE（2025版）

摘要： Peroxisomes are critical organelles that maintain cellular redox homeostasis. Many viruses induce oxidative stress and degrade peroxisomes, but the mechanisms and consequences remain unclear. In this study, we systematically investigate how virus-induced pexophagy regulates peroxisome homeostasis. Using Newcastle disease virus (NDV) as a model, we demonstrate that NDV infection triggers excessive reactive oxygen species (ROS) production, activating the phosphorylation and peroxisomal localization of ataxia-telangiectasia mutated (ATM). Activated ATM promotes the interaction between the peroxisomal receptor PEX5 and the autophagy receptor p62, driving pexophagy. Pexophagy-mediated peroxisome degradation leads to excess active iron and ROS accumulation, contributing to NDV-induced ferroptosis. Notably, this mechanism is shared by other viruses, such as vesicular stomatitis virus and H9N2 avian influenza virus. Our study provides insights into how virus-induced pexophagy disrupts redox homeostasis to promote ferroptosis, highlighting a link between viral infection, peroxisome degradation, and programmed cell death.

分类号：

  • 相关文献

[1]Oocytes maintain low ROS levels to support the dormancy of primordial follicles. Qin, Shaogang,Chi, Xinyue,Zhu, Zijian,Chen, Chuanhe,Zhang, Tuo,He, Meina,Gao, Meng,Zhao, Ting,Zhang, Jingwen,Zhang, Lifan,Zheng, Wenying,Chen, Ziqi,Wang, Wenji,Zhou, Bo,Xia, Guoliang,Wang, Chao. 2024

[2]繁殖与呼吸障碍综合征病毒M蛋白/N蛋白间与N蛋白/3'UTR引入重复序列的反向遗传操作. 郑海红,孙竹筠,丛雁方,张可煜,高飞,童光志. 2019

[3]Fgpex3, A Peroxisome Biogenesis Factor, I.s Involved In Regulating V egetative Growth, Conidiation, Sexual Development, And Virulence In Fusarium Graminearum. Kong, XJ,Zhang, H,Wang, XL,van Der Lee, T,Waalwijk, C,van Diepeningen, A,Brankovics, B,Xu, J,Xu, JS,Chen, WQ,Feng, J. 2019

[4]The M2 Protein of the Influenza A Virus Interacts with PEX19 to Facilitate Virus Replication by Disrupting the Function of Peroxisome. Tanbin Liu,Libin Liang,Pu Zhao,Weipeng Lin,Yichao Zhuang,Li Jiang,Hualan Chen,Chengjun Li. 2024

[5]活性氧在柠檬醛抑制黄曲霉产毒过程中的作用. 李金寒,商博,梁丹丹,Jonathan Nimal Selvaraj,鲁志松,刘阳. 2016

[6]活性氧(ROS)对牛卵母细胞体外成熟凋亡的影响. 刘涛,李向臣,浦亚斌,姚雅馨,关伟军,马月辉. 2010

[7]低氧适应的线粒体调控机制研究进展. 左清清,姚娜,董坤哲,叶绍辉,马月辉. 2013

[8]OsPHGPx基因的过量表达增强水稻抗氧化能力. 宋建辉,李甜,吴秀云,吴赴清,刘进元. 2014

[9]赭曲霉毒素A诱导Caco-2细胞的细胞毒性及DNA损伤. 张捷,李发弟,李爱军,郑楠,李松励,王加启. 2016

[10]烟草转录因子NtNAC080在非生物胁迫下的表达分析及功能鉴定. 文利超,熊涛,邓智超,刘涛,郭存,李伟,郭永峰. 2023

[11]AP2转录因子Oserf34正向调控水稻种子休眠. 杜志敏,贾一楠,段影青,曹妮,马刘洋,董欣丽,徐海,焦桂爱,唐绍清,胡培松. 2025

[12]弓形虫TR与ROP5双基因缺失株的构建及其生物学功能研究. 耿小玲,李瑞芳,徐卫兵,杜晶莹,张曼玉,孙卿,蒋蔚,米荣升,陈兆国,王权. 2025

[13]An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein. Chu Zhang,Fan Yang,Justyna Aleksandra Wojdyla,Bo Qin,Wei Zhang,Min Zheng,Weijun Cao,Meitian Wang,Xiaopan Gao,Haixue Zheng,Sheng Cui. 2022

[14]Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats. Jin Tian,Jiumeng Sun,Dongyan Li,Ningning Wang,Lifang Wang,Chang Zhang,Xiaorong Meng,Xiang Ji,Marc A. Suchard,Xu Zhang,Alexander Lai,Shuo Su,Michael Veit. 2022

[15]N6-methyladenosine modification of the mRNA for a key gene in purine nucleotide metabolism regulates virus proliferation in an insect vector. Zhu M.,Wu N.,Zhong J.,Chen C.,Liu W.,Ren Y.,Wang X.,Jin H.. 2024

[16]Pseudomonas syringae lytic transglycosylase HrpH interacts with host ubiquitin ligase ATL2 to modulate plant immunity. Jun Zhou Li,Yi Lin Gu,Wei Zhang,Shen Cong,Ruo Na Wang,Yi Nan Ma,Ya Jin,Hai Lei Wei. 2025

[17]Bile acid synthesis dysregulation in liver diseases promotes ectopic expansion of oral streptococci in the intestine. Yugui Wang,Wenjie Mu,Jian Guan,Pingping Ma,Yaqi Li,Ying Zhang,Wenjun Zhu,Yu Zhou,Yang Zou,Tongxu Zeng,Jian Zhou,Xiaoqi Lin,Xuehua Yan,Wenjuan Shi,Xiaola Guo,Xing Quan Zhu,Xuepeng Cai,Yan Sun,Aijiang Guo,Shuai Wang. 2025

[18]In toto imaging shows intravascular proliferation promotes transmigration of daughter cells during brain invasion of Cryptococcus neoformans. Ge Wang,Chenxu Feng,Ziyi Ma,Lu Zhao,Mohammed Yosri,Yixuan Wang,Xiang Gao,Weiwei Zhu,Hongmei Li,Haihan Song,Jianhua Xia,Mei Meng,Hongzhong Lu,Lisheng Zhang,Zongyan Chen,Donglei Sun. 2025

[19]Combined ecotoxicological effects of different-sized polyethylene microplastics and imidacloprid on the earthworms (Eisenia fetida). Fu H.,Zhu L.,Mao L.,Zhang L.,Zhang Y.,Chang Y.,Liu X.,Jiang H.. 2023

[20]Microcystin-LR induces ferroptosis in intestine of common carp (Cyprinus carpio). Yuanyuan Zhang,Di Wu,Ze Fan,Jinnan Li,Lei Gao,Yu'e Wang,Liansheng Wang. 2021

作者其他论文 更多>>