数字农科院2.0

Ionic liquid-derived carbon dots with enhanced antibacterial activity and antibiofilm capability for treatment of MRSA-infected wounds

文献类型： 外文期刊

作者： Chenxi Gao;Xiaoqing Qu;Lei Fu;Jia Chen;Yuefeng Chu;Hongdeng Qiu

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关键词： Enhanced antimicrobial activity;Inhibition of biofilm formation;Ionic liquid-derived carbon dots;MRSA-infection wound healing;Selective bacterial inhibition properties

期刊名称： Chemical Engineering Journal

ISSN： 1385-8947

年卷期： 2024 年 497 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Bacterial resistance to antibiotics has rendered bacterial infections an escalating threat to public health, prompting numerous researchers to strive towards the development of novel antimicrobial agents. Designable ionic liquids (ILs) have gained increasing prominence in the field of antibacterials. However, certain ILs exhibit suboptimal antimicrobial activity. In this study, we synthesized ionic liquid-derived carbon dots (IL-CDs: VOIMBr-CD) through vinyl and epoxy group reactions, resulting in enhanced antimicrobial efficacy. The VOIMBr-CD retains the antibacterial structure characteristic of ILs, including a positively charged imidazolium group and long alkyl chain. Moreover, VOIMBr-CD demonstrates selective antibacterial action against Staphylococcus aureus (S. aureus) while effectively inhibiting S. aureus biofilm growth. Notably, the antibacterial efficacy of VOIMBr-CD against methicillin-resistant Staphylococcus aureus (MRSA), surpasses vancomycin (Van). We conducted comprehensive investigations into the selective antibacterial mechanism of VOIMBr-CD which primarily involves electrostatic interactions, hydrophobic interactions, as well as generation of reactive oxygen species (ROS) within bacteria cells. In vivo experiments demonstrated that VOIMBr-CD significantly alleviate inflammation, facilitated collagen deposition and angiogenesis, and effectively expedited wound healing in MRSA-infected mice models; thus, highlighting their potential as therapeutic candidates for diseases resembling MRSA infection-like conditions. Importantly, this work presents a novel approach utilizing IL-based materials for developing effective antibacterials thereby offering new insights into the application prospects of IL-derived materials.

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