Development Of Small Molecule Biosensors B.y Coupling The Recognition O f The Bacterial Allosteric Transcription Factor With Isothermal Strand Displacement Amplification
文献类型： 外文期刊
作者： Wang, Weishan;Kong, Deming;Yang, Keqian;Fan, Keqiang;Liu, Weiwei;Cao, Jiaqian;Yao, Yongpeng;Liu, Weiwei;Yao, Yongpeng;Li, Shanshan;Xiang, Wensheng;Cao, Jiaqian
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期刊名称： CHEMICAL COMMUNICATIONS
ISSN： 1359-7345
年卷期： 2018 年 54 卷 38 期
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摘要： Here, we demonstrate an easy-to-implement and general bio-sensing strategy by coupling the small-molecule recognition of the bacterial allosteric transcription factor (aTF) with isothermal strand displacement amplification (SDA) in vitro. Based on this strategy, we developed two biosensors for the detection of an antiseptic, p-hydroxybenzoic acid, and a disease marker, uric acid, using bacterial aTF HosA and HucR, respectively, highlighting the great potential of this strategy for the development of small-molecule biosensors.
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