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Altered Serum Metabolite Profiling And R.elevant Pathway Analysis In R ats Stimulated By Honeybee Venom: New Insight Into Allergy To Honeybee Venom

文献类型： 外文期刊

作者： Zhao, YZ; Zhang, JM; Chen, YP; Li, ZG; Nie, HY; Peng, WJ; Su, SK

作者机构：

关键词： honeybee venom stimulation; serum metabonomics; metabolite profiling; H-1 NMR

期刊名称： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN： 0021-8561

年卷期： 2018 年 66 卷 4 期

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： To improve our understanding of the disturbed metabolic pathways and cellular responses triggered by honeybee venom stimulation, we compared the changes in serum metabolites in rats, either stimulated or not by honeybee venom, by performing H-1 nuclear magnetic resonance (NMR) spectrometry-based metabonomics to identify potential biomarkers. In this study, 65 metabolites were structurally confirmed and quantified and the following results were obtained. First, by pattern recognition analysis, 14 metabolites were selected as potential biomarkers 3 h after venom stimulation. Second, metabolic pathway analysis showed that methane metabolism, glyoxylate and dicarboxylate metabolism, tricarboxylic acid cycle, glycine, serine, and threonine metabolism, arginine and proline metabolism were affected. Finally, the time-dependent metabolic modifications indicated that rats could recover without medical treatment 24 h after venom stimulation. In summary, this new insight into the changes in serum metabolites in rats after honeybee venom stimulation has enhanced our understanding of the response of an organism to honeybee venom.

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