数字农科院2.0

An Efficient Novel Synthesis Of 1.4-O-[(4-Amino-6-Hydroxy-Pyrimidine-2-Yl)Thioacetyl]Mutilin And The Antibacterial E valuation

文献类型： 外文期刊

作者： Shang Ruo-Feng;Xu Wen-Jun;Yi Yun-Peng;Huang Xin;Xu Wen-Jun;Liang Jian-Ping

作者机构：

关键词： pleuromutilin; single-crystal structure; antibacterial activities

期刊名称： CHINESE JOURNAL OF STRUCTURAL CHEMISTRY

ISSN： 0254-5861

年卷期： 2017 年 36 卷 9 期

页码：

摘要： The title structure of 14-O-[(4-amino-6-hydroxy-pyrimidine-2-yl)thioacetyl]mutilin, C26H47N3O5S, has been synthesized using 22-O-tosyl pleuromutilin and 4-amine-6-hydroxy-2-mercatopyrimidine monohydrate, and its structure was characterized by IR, NMR, H RMS and single-crystal X-ray diffraction. This compound has a 5-6-8 tricyclic carbon skeleton and a pyrimidine ring. It crystallizes in orthorhombic, space group P2(1)2(1)2(1) with a = 10.494(3), b = 16.997(5), c = 16.997 angstrom, Z = 4, D-c = 1.275 Mg.m(-3), mu = 0.220 mm(-1), F(000) = 1248, wR(F-2) = 0.1159 and R = 0.0381. The preliminary biological test showed that the title compound has more potent inhibitions to Staphylococcus aureus, MRSA and MRSE than that of tiamulin fumarate in vitro.

分类号：

  • 相关文献

[1]Synthesis, Crystal Structure And Biological E.valuation Of 14-O-[(2-Chloroacetamide-6-Aminopyrimidine-2-Yl)Thioacetyl] Mutilin. Wang Liang,Zhou Xiang,Shang Ruo-Feng,Yi Yun-Peng,Wang Liang,Xin Zhi-Jun,Liang Jian-Ping,Lu Xi-Hong,Li Xue-Hu. 2017

[2]Synthesis, Crystal Structure And Biological E.valuation Of 6 '-Chloro-4 ' -Methylene-3H-Spiro[Isobenzofuran-1,3 '-Isochroman]. Hao Bao-Cheng,Xu Wen-Jun,Liang Jian-Ping,Li Hao-Wen,Xu Wen-Jun,Pu Xiu-Ying,Yi Yun-Peng,Pu Xiu-Ying. 2019

[3]Antibacterial Activity And Mechanism Of T.he Ethanol Extracts From S onchus Brachyotus Dc.. Li, XM, Liu, J, Du, YK, Wen, ZG, Wang, JT, Yang, PL. 2017

[4]Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives. Liu, Huixian,Xiao, Sui,Zhang, Lifang,Wang, Xiaoyang,Xue, Feiqun,Zhang, Depeng,Mu, Shuhua.

[5]Efficient antibacterial agents: A review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives. Shang, Ruofeng,Guo, Wenzhu,Liang, Jianping,Wang, Jiatu.

[6]Design and Synthesis of Pleuromutilin Derivatives as Antibacterial Agents Using Quantitative Structure-Activity Relationship Model. Jiaming Zhang,Qinqin Liu,Haoxia Zhao,Guiyu Li,Yunpeng Yi,Ruofeng Shang. 2024

[7]Synthesis and biological activity evaluation of a novel pleuromutilin derivative 22-((2-methyl-1-(1H-pyrrole-2-carboxamido)propan-2-yl)thio)-deoxypleuromutilin. Zhun Li,Danqian Ma,Chang Liu,Zhe Qin,Lixia Bai,Wenbo Ge,Xiao Xu,Jianyong Li. 2025

[8]Design, synthesis, and bioactivity of newly potent pleuromutilin derivatives. Zhun Li,Danqian Ma,Chang Liu,Xianlong Qi,Zhe Qin,Yajun Yang,Jianyong Li. 2025

作者其他论文 更多>>