文献类型: 外文期刊
作者: Zhu, L; Wang, P; Yuan, W; Zhu, G
作者机构:
关键词: BoHV-1; inflammation; Kaempferol; cytokine
期刊名称: ACTA VIROLOGICA
ISSN: 0001-723X
年卷期: 2018 年 62 卷 2 期
页码:
收录情况: JCR(2021版)
摘要: Plant-derived flavonoids contain large amount of compounds with pharmacological effects. In this study, we showed the compound Kaempferol to have robust antiviral activity against bovine herpesvirus 1 (BoHV-1) replication in vitro. Kaempferol at a concentration of 100 mu mol/l completely inhibited viral replication in MDBK cells. It mainly affects the viral replication at the post-entry stages. The inhibition of Akt signaling is a potential mechanism underlying the antiviral effect of Kaempferol. In addition, at a concentration of 25 and 50 mu mol/l Kaempferol could significantly reduce the expression of inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), interleukin 8 (IL-8) and macrophage inflammatory protein 1 alpha (MIP-1 alpha) in human promonocytic U937 cells-derived macrophages (dU937) in response to lipopolysaccharides (LPS) stimulation. Overall, our results indicated that Kaempferol provides a potent protection against BoHV-1 infection and LPS-induced inflammatory response.
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