数字农科院2.0

Effect Of A Novel Antifungal P.eptide P852 On Cell M orphology And Membrane Permeability Of Fusarium Oxysporum

文献类型： 外文期刊

作者： Han, YZ; Zhao, JJ; Zhang, B; Shen, Q; Shang, QM; Li, PL

作者机构：

关键词： Antifungal peptide; Fusarium oxysporum; Membrane permeabilization; Cell morphology

期刊名称： BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ISSN： 0005-2736

年卷期： 2019 年 1862 卷 2 期

页码：

收录情况： JCR（2021版）

摘要： P852, a novel cyclic peptide isolated from Bacillus amyloliquefaciens L-H15, showed potent antifungal activity against several major plant fungal pathogens including Fusarium oxysporum. To elucidate the antifungal mechanism, the impact of P852 on the cell morphology and membrane permeabilization of F. oxysporum was studied. By applying electron microscopy and fluorescent techniques, we showed that P852 treatment caused the morphological change of F. oxysporum cells and disrupted its cell structure, including formation of blebs, broken hyphae, deformation of membrane, intracellular organization disruption, pore formation, and cell lysis. Our findings provide insights into the mode of action of P852, which laying a foundation to develop P852 as a novel antifungal agent to control plant fungal pathogens.

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