数字农科院2.0

Pollen Reverses Decreased Lifespan, Altered N.utritional Metabolism And Suppressed I mmunity In Honey Bees (Apis Mellifera) Treated With Antibiotics

文献类型： 外文期刊

作者： Li, JH; Heerman, MC; Evans, JD; Rose, R; Li, WF; Rodriguez-Garcia, C; DeGrandi-Hoffman, G; Zhao, YZ; Huang, SK; Li, ZG; Hamilton, M; Chen, YP

作者机构：

关键词： Gut bacteria; Nutrition metabolism; Immunity; Deformed wing virus; DWV

期刊名称： JOURNAL OF EXPERIMENTAL BIOLOGY

ISSN： 0022-0949

年卷期： 2019 年 222 卷 7 期

页码：

收录情况： JCR（2021版）

摘要： Nutrition is involved in regulating multiple aspects of honey bee biology such as caste, immunity, lifespan, growth and behavioral development. Deformed wing virus (DWV) is a major pathogenic factor which threatens honey bee populations, and its replication is regulated by the nutrition status and immune response of honey bees. The alimentary canal of the honey bee is home to a diverse microbial community that provides essential nutrients and serves to bolster immune responses. However, to what extent gut bacteria affect honey bee nutrition metabolism and immunity with respect to DWV has not been investigated fully. In this study, newly emerged worker bees were subjected to four diets that contained (1) pollen, (2) pollen and antibiotics, (3) neither pollen nor antibiotics or (4) antibiotics alone. The expression level of two nutrition genes target of rapamycin (tor) and insulin like peptide (ilp1), one nutritional marker gene vitellogenin (vg), five major royal jelly protein genes (mrjp1-5), one antimicrobial peptide regulating gene relish (rel), and DWV virus titer and its replication intermediate, negative RNA strand, were determined by qRT-PCR from the honey bees at 7 days post-antibiotic treatment. Additionally, honey bee head mass and survival ratewere measured. We observed that antibiotics decreased the expression of tor and rel, and increased DWV titer and its replication activity. Expression of ilp1, mrjp1-5 and vg, and honey bee head mass were also reduced compared with bees on a pollen diet. Antibiotics also caused a significant drop in survivorship, which could be rescued by addition of pollen to the diet. Of importance, pollen could partially rescue the loss of vg and mrjp2 while also increasing the head mass of antibiotic-treated bees. Our results illuminate the roles of bacteria in honey bee nutrition, metabolism and immunity, which confer the ability to inhibit virus replication, extend honey bee lifespan and improve overall health.

分类号：

  • 相关文献

[1]Occurrence and molecular phylogeny of honey bee viruses in Vespids. Hou, Chunsheng,Gayral, Philippe,Bigot, Diane,Deng, Shuai,Li, Fei,Diao, Qingyun,Wu, Yaojun,Jiang, Xuejian,Bigot, Diane,Herniou, Elisabeth A.,Darrouzet, Eric,Zhao, Hongxia,Yang, Dahe,Deng, Shuai,Li, Fei,Yang, Sa,Wu, Yanyan,Wang, Xinling,Wu, Yanyan,Wang, Xinling,Yang, Dahe,Diao, Qingyun,Hou, Chunsheng,Yang, Sa. 2020

[2]Effects of dietary scFOS and lactobacilli on survival, growth, and disease resistance of hybrid tilapia. Liu, Wenshu,Wang, Wenwen,Ran, Chao,He, Suxu,Yang, Yaling,Zhou, Zhigang,Liu, Wenshu.

[3]High-fiber diet and rope-skipping benefit cardiometabolic health and modulate gut microbiota in young adults: A randomized controlled trial. Zongyu Lin,Xin Zhang,Miao Wu,Yingan Ming,Xiaotong Wang,Hailin Li,Fenglian Huang,Fei Gao,Yanna Zhu. 2023

[4]Effects of choline chloride on intestinal microbiota and its association with liver fat accumulation in zebrafish. Wenshu Liu,Xiaoze Guo,Yanliang Chen,Yanqiang Tang,Haihong Xiao,Yuzhu Wang,Siming Li,Zhigang Zhou. 2022

[5]Identification of WxL and S-Layer Proteins from Lactobacillus brevis with the Ability to Bind Cellulose and Xylan. Zhenzhen Hao,Wenjing Zhang,Xiaolu Wang,Yuan Wang,Xing Qin,Huiying Luo,Huoqing Huang,Xiaoyun Su. 2022

[6]Gut symbiotic bacteria enhance reproduction in Spodoptera frugiperda (J.E. Smith) by regulating juvenile hormone III and 20-hydroxyecdysone pathways. Bo Chu,Shishuai Ge,Wei He,Xiaoting Sun,Jiajie Ma,Xianming Yang,Chunyang Lv,Pengjun Xu,Xincheng Zhao,Kongming Wu. 2025

[7]Native mid-gut bacterial community increases resistance to nucleopolyhedrovirus in the cotton leafworm. Tong Li,Yueli Jiang,Yunhui Zhang,Yuqing Wu,Kenneth Wilson,Pengjun Xu. 2025

[8]Gut bacteria are essential for development of an invasive bark beetle by regulating glucose transport. Fanghua Liu,Fangyuan Ye,Yunwen Yang,Zhiwei Kang,Yang Liu,Wei Chen,Saige Wang,Hongru Kou,Le Kang,Jianghua Sun. 2024

[9]Nonspecific Binding of a Putative S-Layer Protein to Plant Cell Wall Polysaccharides—Implication for Growth Competence of Lactobacillus brevis in the Gut Microbiota. Zhenzhen Hao,Wenjing Zhang,Jianzhong Ge,Daoxin Yang,Kairui Guo,Yuan Wang,Huiying Luo,Huoqing Huang,Xiaoyun Su. 2025

[10]Corn peptides alleviate high-fat diet-induced obesity and metabolic disorders in mice by regulating adipogenesis and intestinal microbial disorders. Feng, Zhiyuan,Yong, Wang、张瑞雪、Li, Mingliang,Pang, Meixia,Zhang, Xinru,Wei, Ying,Sun, Guiju. 2025

[11]Silkworm (Bombyx mori) gut bacteria respond positively to exposure of magnetic Fe3O4@urease-doped nanoconjugates: potential reconstruction for nutritional efficiency. Herman, Richard Ansah,Khurshid, Marriam,Zhang, Zhan-Peng,Yan, Cheng-Hai,Ayepa, Ellen,Li, Yi-Jiang-Cheng,You, Shuai,Sheng, Sheng,Wang, Jun. 2025

[12]The host phylogeny and climate determine the gut bacteria of global insects. Shiqing Nie,Yong Jun Liu,Yuan Ge. 2025

[13]Rna-Sequencing, Physiological And Rnai Analyses P.rovide Insights Into The R esponse Mechanism Of The Abc-Mediated Resistance To Verticillium Dahliae Infection In Cotton. Peng, Renhai,Magwanga, Richard Odongo,Lu, Pu,Wang, Kunbo,Wang, Xingfen,Zhou, Zhongli,Xu, Yanchao,Wang, Xingxing,Cai, Xiaoyan,Dong, Qi,Dong, Qi,Hou, Yuqing,Magwanga, Richard Odongo,Liu, Fang,Kirungu, Joy Nyangasi,Ma, Zhiying. 2019

[14]Immunoregenerative Effects Of The Bionically C.ultured Sanghuang Mushrooms (Inonotus S anghuagn) On The Immunodeficient Mice. Shen, Yi,Shen, Yi,Wang, Jun,Wen, Yan,Wang, Jun,Wan, Yi:zhen,Xu, Xiao:Feng,Wen, Yan,Wan, Yi:zhen,Qiao, Chun:xia,Wen, Yan. 2019

[15]Prospects Of Hsp70 As A Genetic Marker For Thermo-Tolerance And Immuno-Modulation In Animals Under Climate Change Scenario. Hassan, Faiz-ul,Yang, Chengjian,Nawaz, Ayesha,Hassan, Faiz-ul,Hassan, Faiz-ul,Rehman, Muhammad S.,Ali, Muhammad A.,Yang, Chengjian,Dilshad, Syed M. R.. 2019

[16]Antimicrobial Peptide Gene Bdpho Responds T.o Peptidoglycan Infection And M ating Stimulation In Oriental Fruit Fly, Bactrocera Dorsalis (Hendel). Liu, Shi-Huo,Jiang, Hong-Bo,Dou, Wei,Dou, Wei,Li, Hong-Fei,Jiang, Hong-Bo,Wei, Dong,Yuan, Guo-Rui,Liu, Shi-Huo,Wang, Jin-Jun,Wei, Dong,Yang, Yang,Wang, Jin-Jun. 2018

[17]Overview Of Folic Acid Supplementation Alone Or In Combination With Vitamin B12 In Dairy Cattle During Periparturient Period. Liu, Lei,Yu, Ying,Liu, Lei,Dou, Jinhuan,Liu, Lei,Dou, Jinhuan,Khan, Muhammad Zahoor,Khan, Muhammad Zahoor,Khan, Adnan,Yu, Ying,Xiao, Jianxin,Khan, Adnan. 2020

[18]Dendritic Cell Harmonised Immunity To P.oultry Pathogens; A Review. Rehman, ZU, Umar, S, Meng, C, Ullah, Z, Riaz, F, Rehman, SU, Ding, C. 2017

[19]Effect Of Dietary Supplementation Of P.hytochemicals On Immunity And H aematology Of Growing Broiler Chickens. Kamboh, AA, Khan, MA, Kaka, U, Awad, EA, Memon, AM, Saeed, M, Korejo, NA, Bakhetgul, M, Kumar, C. 2018

[20]Early Microbial Colonization Affects Dna M.ethylation Of Genes Related T o Intestinal Immunity And Metabolism In Preterm Pigs. Duc Ninh Nguyen,Gao, Fei,Zhang, Xinxin,Fredholm, Merete,Fredholm, Merete,Lu, Hanlin,Hu, Qi,Gong, Desheng,Pan, Xiaoyu,Sangild, Per T.. 2018

作者其他论文 更多>>