Study On Antidepressant Activity Of P.seudo-Ginsenoside Hq On Depression-Like B ehavior In Mice
文献类型： 外文期刊
作者： Chen, LX; Qi, Z; Shao, ZJ; Li, SS; Qi, YL; Gao, K; Liu, SX; Li, Z; Sun, YS; Li, PY
作者机构：
关键词： ginsenoside Rh-2; (24R)-pseudo-ginsenoside HQ; (24S)-pseudo-ginsenoside HQ; LPS-induced depression
期刊名称： MOLECULES
ISSN： 1420-3049
年卷期： 2019 年 24 卷 5 期
页码：
收录情况： JCR（2021版）
摘要： Suppressive effects of ginsenoside Rh-2 (Rh-2), (24R)-pseudo-ginsenoside HQ (R-PHQ), and (24S)-pseudo-ginsenoside HQ (S-PHQ) against lipopolysaccharide (LPS)-induced depression-like behavior were evaluated using the forced swimming test (FST) and tail suspension test (TST) in mice. Pretreatment with Rh-2, R-PHQ, and S-PHQ significantly decreased immobility time in FST and TST with clear dose-dependence, and significantly downregulated levels of serum tumor necrosis factor-alpha and interleukin-6, and upregulated superoxide dismutase activity in the hippocampus of LPS-challenged mice. Furthermore, R-PHQ and S-PHQ significantly increased the expression of the brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB), sirtuin type 1 (Sirt1), and nuclear-related factor 2, and inhibited the phosphorylation of inhibitor of kappa B-alpha and nuclear factor-kappa B (NF-kappa B) in the hippocampus of LPS-challenged mice. Additionally, the antidepressant-like effect of R-PHQ was found related to the dopaminergic (DA), gamma-aminobutyric acid (GABA)ergic, and noradrenaline systems, while the antidepressive effect of S-PHQ was involved in the DA and GABAergic systems. Taken together, these results suggested that Rh-2, R-PHQ, and S-PHQ produced significant antidepressant-like effects, which may be related to the BDNF/TrkB and Sirt1/NF-kappa B signaling pathways.
分类号：
- 相关文献
作者其他论文 更多>>
-
Flowering Locus T Improves Cucumber Adaptation To Higher Latitudes
作者：Wang, SH; Li, HB; Li, YY; Li, Z; Qi, JJ; Lin, T; Yang, XY; Zhang, ZH; Huang, SW
关键词：
-
Behavior Of Microplastics And Plastic Film Residues In The Soil Environment: A Critical Review
作者：Qi, RM; Jones, DL; Li, Z; Liu, Q; Yan, CR
关键词：Environmental Risk; Nanoplastics; Soil Heath; Mulching Film; Plasticizer
-
Effects Of Agricultural Plastic Film Residues On Transportation And Distribution Of Water And Nitrate In Soil
作者：Li, YQ; Zhao, CX; Yan, CR; Mao, LL; Liu, Q; Li, Z; He, WQ
关键词：Plastic-Film Residues; Soil Structure; Water Transportation; Water And Nitrate Distribution; Wetted Volume
-
Mir-187-5P/Apaf-1 Axis Was Involved In Oxidative Stress-Mediated Apoptosis Caused By Ammonia Via Mitochondrial Pathway In Chicken Livers
作者：Xu, YM; Li, Z; Zhang, S; Zhang, HF; Teng, XH
关键词：Nh3; Chicken; Liver; Mir-187-5P; Apoptosis; Mitochondrial Pathway
-
The Responses Of Cadmium Phytotoxicity In Rice And The Microbial Community In Contaminated Paddy Soils For The Application Of Different Long-Term N Fertilizers
作者：Wang, M; Chen, SB; Zheng, H; Li, SS; Chen, L; Wang, D
关键词：Cadmium; Long-Term N Fertilization; Bacteria; Fungi; Microbial Community
-
The Structure Features And Improving Effects Of Polysaccharide From Astragalus Membranaceus On Antibiotic-Associated Diarrhea
作者：Li, SH; Qi, YL; Ren, DD; Qu, D; Sun, YS
关键词：Astragalus Membranaceus; Polysaccharide; Antibiotic-Associated Diarrhea; Gut Microbiota; Short-Chain Fatty Acids
-
A Framework For Evaluating County-Level Non -Point Source Pollution: Joint Use Of Monitoring And Model Assessment
作者：Shen, WZ; Zhang, L; Li, SS; Zhuang, YH; Liu, HB; Pan, JT
关键词：Administrative Boundary; Critical Source Areas; Environmental Monitoring; Management Measure; Nonpoint Source Pollution