Toll-Like Receptor 2-Mediated Induction Of A.vian Beta-Defensin 9 By L actobacillus Rhamnosus And Its Cellular Components In Chicken Intestinal Epithelial Cells
文献类型： 外文期刊
作者： Jia, YJ; Si, W; Hong, ZM; Qu, MR; Zhu, NH; Liu, SG; Li, GH
作者机构：
关键词： Avian beta-defensin 9 (AvBD9); Toll-like receptor 2 (TLR2); chicken intestinal epithelial cells; Lactobacillus rhamnosus; peptidoglycan
期刊名称： FOOD AND AGRICULTURAL IMMUNOLOGY
ISSN： 0954-0105
年卷期： 2019 年 30 卷 1 期
页码：
收录情况： JCR（2021版）
摘要： This study aimed to investigate the effects of probiotic Lactobacillus rhamnosus MLGA and its cell wall components on the induction of avian beta-defensin 9 (AvBD9) expression in intestinal epithelial cells (IECs) from chicken embryos and to elucidate the underlying mechanism. Chicken IECs were stimulated with L. rhamnosus MLGA or cell wall components. Quantitative RT-PCR analysis was used to determine the expressions of target genes. L. rhamnosus MLGA and its cellular components significantly induced AvBD9 and TLR2 expression, with the whole peptidoglycan (WPG) being the most potent inducer. Pretreatment of chicken IECs with a TLR2 neutralizing antibody diminished AvBD9 induction by L. rhamnosus MLGA and WPG. The inhibition tests showed that induction of AvBD9 in IECs by L. rhamnosus MLGA and WPG was dependent on NF-kappa B or JNK pathways. These results demonstrate that L. rhamnosus MLGA and WPG induce AvBD9 expression in chicken IECs via a TLR2-mediated NF-kappa B/JNK pathway.
分类号：
- 相关文献
作者其他论文 更多>>
-
A Multivalent Vaccine Candidate Targeting Enterotoxigenicescherichia Colifimbriae For Broadly Protecting Against Porcine Post-Weaning Diarrhea
作者：Duan, QD; Pang, SM; Wu, WW; Jiang, BY; Zhang, WP; Liu, SG; Wang, XJ; Pan, ZM; Zhu, GQ
关键词：Etec; Pwd; Fimbriae; Mefa; Vaccine
-
Characterization And Pathogenicity Of Extracellular Serine Protease Map3292C From Mycobacterium Avium Subsp. Paratuberculosis
作者：Liu, HX; Dang, GH; Zang, XX; Cai, ZM; Cui, ZY; Song, NN; Liu, SG
关键词：Mycobacterium Avium Subsp. Paratuberculosis; Map3292C; Serine Protease; Mycobacterium Smegmatis; Pathogenicity
-
Basal-Level Effects Of (P)Ppgpp In The Absence Of Branched-Chain Amino Acids In Actinobacillus Pleuropneumoniae
作者：Li, G; Zhao, Q; Luan, T; Hu, YB; Zhang, YL; Li, T; Wang, CL; Xie, F; Zhang, WJ; Langford, PR; Liu, SG
关键词：Actinobacillus Pleuropneumoniae; Stringent Response; Bcaas; (P)Ppgpp; Gtp
-
Regulation Of Plant Architecture By A New Histone Acetyltransferase Targeting Gene Bodies
作者：Yang, XY; Yan, JB; Zhang, Z; Lin, T; Xin, TX; Wang, BW; Wang, SH; Zhao, JC; Zhang, ZH; Lucas, WJ; Li, GH; Huang, SW
关键词：
-
Assessment Of The Resilience In Sepls (Socio-Ecological Production Landscapes And Seascapes) In Yanuo Village, Xishuangbanna, Southwest China
作者：Yang, YH; Bai, KY; Li, GH; Jarvis, DI; Long, CL
关键词：Sepls; Resilience; Ecosystem Services; Xishuangbanna; Decision Framework
-
A Unique Combination Of Glycoside Hydrolases In Streptococcus Suis Specifically And Sequentially Acts On Host-Derived Alpha Gal-Epitope Glycans
作者：Chen, P; Liu, R; Huang, MM; Zhu, JL; Wei, D; Castellino, FJ; Dang, GH; Xie, F; Li, G; Cui, ZY; Liu, SG; Zhang, YL
关键词：Streptococcus Suis; Glycoside Hydrolase (Gh); Multifunctional Enzyme; Family 32 Carbohydrate-Binding Module (Cbm32); Evolution; Alpha Gal Epitope; Swine Tracheal Epithelial Cells (Stec); Endo-(Beta 1; 4)-Galactosidase; Beta-Acetylhexosaminidase; Galnaga; Streptococcus; Substrate Specificity; Multifunctional Enzyme; Carbohydrate-Binding Protein; Carbohydrate Processing; Enzyme Catalysis; Enzyme Kinetics; Host-Pathogen Interaction; Erythrocyte
-
Virus-Like Particles Derived From A Virulent Strain Of Pest Des Petits Ruminants Virus Elicit A More Vigorous Immune Response In Mice And Small Ruminants Than Those From A Vaccine Strain
作者：Yan, FH; Li, ET; Li, L; Schiffman, Z; Huang, P; Zhang, SN; Li, GH; Jin, HL; Wang, HL; Zhang, XH; Gao, YW; Feng, N; Zhao, YK; Wang, CY; Xia, XZ
关键词：Peste Des Petits Ruminants Virus; Virus-Like Particles; Small Ruminants; Virulent Strain; Vaccine Strain; Immune Response