数字农科院2.0

Metabolomic Signature Of Mouse Cerebral C.ortex Following Toxoplasma Gondii I nfection

文献类型： 外文期刊

作者： Ma, J; He, JJ; Hou, JL; Zhou, CX; Zhang, FK; Elsheikha, HM; Zhu, XQ

作者机构：

关键词： Metabolomics; Neuropathy; Cerebral cortex; Toxoplasma gondii; Host-parasite interaction; Metabolism

期刊名称： PARASITES & VECTORS

ISSN： 1756-3305

年卷期： 2019 年 12 卷

页码：

收录情况： JCR（2021版）

摘要： BackgroundThe protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contribute to these changes remain largely unknown.MethodsWe have investigated the impact of T. gondii infection on the overall metabolism of mouse cerebral cortex. Mass-spectrometry-based metabolomics and multivariate statistical analysis were employed to discover metabolomic signatures that discriminate between cerebral cortex of T. gondii-infected and uninfected control mice.ResultsOur results identified 73, 67 and 276 differentially abundant metabolites, which were involved in 25, 37 and 64 pathways at 7, 14 and 21days post-infection (dpi), respectively. Metabolites in the unsaturated fatty acid biosynthesis pathway were upregulated as the infection progressed, indicating that T. gondii induces the biosynthesis of unsaturated fatty acids to promote its own growth and survival. Some of the downregulated metabolites were related to pathways, such as steroid hormone biosynthesis and arachidonic acid metabolism. Nine metabolites were identified as T. gondii responsive metabolites, namely galactosylsphingosine, arachidonic acid, LysoSM(d18:1), l-palmitoylcarnitine, calcitetrol, 27-Deoxy-5b-cyprinol, l-homophenylalanine, oleic acid and ceramide (d18:1/16:0).ConclusionsOur data provide novel insight into the dysregulation of the metabolism of the mouse cerebral cortex during T. gondii infection and have important implications for studies of T. gondii pathogenesis.

分类号：

  • 相关文献

[1]Effect of deletion of gra17 and gra23 genes on the growth, virulence and immunogenicity of type II Toxoplasma gondii.. . 2020

[2]Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Reveals Metabolic Alterations In The Mouse Cerebellum Duringtoxoplasma Gondiiinfection. Ma, J, He, JJ, Hou, JL, Zhou, CX, Elsheikha, HM, Zhu, XQ. 2020

[3]Ameliorative Effects Of Taurine Against D.iabetes: A Review. Inam-u-Ilah, Piao, FY, Aadil, RM, Suleman, R, Li, KX, Zhang, MR, Wu, PA, Shahbaz, M, Ahmed, Z. 2018

[4]Acute Toxoplasma Gondii Infection In C.ats Induced Tissue-Specific Transcriptional R esponse Dominated By Immune Signatures. Cong, W, Dottorini, T, Khan, F, Emes, RD, Zhang, FK, Zhou, CX, He, JJ, Zhang, XX, Elsheikha, HM, Zhu, XQ. 2018

[5]The Multitasking Fasciola Gigantica Cathepsin B. Interferes With Various F unctions Of Goat Peripheral Blood Mononuclear Cells In Vitro. Chen, D, Tian, AL, Hou, JL, Li, JX, Tian, XW, Yuan, XD, Li, XR, Elsheikha, HM, Zhu, XQ. 2019

[6]Quantitative proteomics reveals tissue-specific toxic mechanisms for acute hydrogen sulfide-induced injury of diverse organs in pig. Liu Z., Chen L., Gao X., Zou R., Meng Q., Fu Q., Xie Y., Miao Q., Chen L., Tang X., Zhang S., Zhang H., Schroyen M.. 2022

[7]Toxoplasma Gondii Clp Family Protein: T.gclpb1 Plays A Crucial R ole In Thermotolerance. Cao, SN, Du, NL, Chen, HM, Pang, Y, Zhang, ZX, Zheng, J, Jia, HL. 2017

[8]Seroprevalence Of Toxoplasma Gondii In S.outh Asian Countries. Khan, MU, Rashid, I, Akbar, H, Islam, S, Riaz, F, Nabi, H, Ashraf, K, Singla, LD. 2017

[9]Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection. Bai, Meng-Jie,Elsheikha, Hany M.,Zhu, Xing-Quan,Wang, Jin-Lei,Liang, Qin-Li,Li, Ting-Ting,Cao, Xue-Zhen. 2020

[10]Biochemical Characterization Of Aminopeptidase N2 F.rom Toxoplasma Gondii. Li, QW, Jia, HL, Cao, SN, Zhang, ZX, Zheng, J, Zhang, YQ. 2017

[11]Toxoplasma Gondii Rop17 Inhibits The I.nnate Immune Response Of H ek293T Cells To Promote Its Survival. Li, JX, He, JJ, Elsheikha, HM, Chen, D, Zhai, BT, Zhu, XQ, Yan, HK. 2019

[12]Prevalence, Risk Factors And Genotype Distribution Of Toxoplasma Gondii Dna In Soil In China. Cong, W, Zhang, NZ, Hu, RS, Zou, FC, Zou, Y, Zhong, WY, Wu, JJ, Fallaize, CJ, Zhu, XQ, Elsheikha, HM. 2020

[13]Molecular Detection And Genotyping Of T.oxoplasma Gondii In Free-Ranging P igs In Northeastern China. Zhang, XX, Jiang, RL, Zhang, NZ, Wang, CR, Tao, WF, Xu, P, Ma, CF, Hou, GY, Ni, HB. 2018

[14]Global phosphoproteome analysis reveals significant differences between sporulated oocysts of virulent and avirulent strains of Toxoplasma gondii. Wang Z.-X.,Hu R.-S.,Zhu X.-Q.,Sun X.-L.,Elsheikha H.M.. 2021

[15]Recombinant Toxoplasma gondii ribosomal protein p2 modulates the functions of murine macrophages in vitro and provides immunity against acute toxoplasmosis in vivo. Yu Zhengqing,Lu Yujia,Liu Zhaoyi,Aleem Muhammad Tahir,Liu Junlong,Luo Jianxun,Yan Ruofeng,Xu Lixin,Song Xiaokai,Li Xiangrui. 2021

[16]Internal daughter formation of Toxoplasma gondii tachyzoites is coordinated by transcription factor TgAP2IX ‐5. Chaoyue Wang,Dandan Hu,Xinming Tang,Xingju Song,Si Wang,Sixin Zhang,Chunhui Duan,Pei Sun,Jingxia Suo,Huiming Ma,Xun Suo,Xianyong Liu. 2021

[17]Lysine crotonylation is widespread on proteins of diverse functions and localizations in Toxoplasma gondii. Fa-Cai Li,Lan-Bi Nie,Hany M. Elsheikha,Fang-Yuan Yin,Xing-Quan Zhu. 2021

[18]Seroepidemiology Of Toxoplasma Gondii Infection I.n Patients With Liver D isease In Eastern China. Tian, AL, Li, GX, Elsheikha, HM, Gardner, DS, Zhang, XY, Dong, W, Yang, XP, Luo, YY, Li, HL, Cong, W, Zhu, XQ. 2017

[19]The Nrf2 Pathway Is Required F.or Intracellular Replication Of T oxoplasma Gondii In Activated Macrophages. Pang, Y, Zhang, ZX, Chen, YT, Cao, SN, Yang, XQ, Jia, HL. 2019

[20]Study on Circulating Antigens in Serum of Mice With Experimental Acute Toxoplasmosis. Qi Liu,Wei Jiang,Yun Chen,Manyu Zhang,Xiaoling Geng,Quan Wang. 2021

作者其他论文 更多>>