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Cholesterol-Reducing Effect Of Ergosterol Is M.odulated Via Inhibition Of C holesterol Absorption And Promotion Of Cholesterol Excretion

文献类型： 外文期刊

作者： He, WS; Cui, DD; Li, LL; Tong, LT; Rui, JX; Li, H; Zhang, HJ; Liu, XQ

作者机构：

关键词： Ergosterol; Cholesterol-lowering; Hypercholesterolemia; Edible mushroom

期刊名称： JOURNAL OF FUNCTIONAL FOODS

ISSN： 1756-4646

年卷期： 2019 年 57 卷

页码：

收录情况： JCR（2021版）

摘要： Ergosterol is the common sterol found in edible mushrooms. This study investigated the cholesterol-reducing effect of ergosterol and its related potential mechanism in Sprague-Dawley rats. Thirty-two male rats were divided into four groups fed either a basic diet (NG) or one of three experimental diets, namely high-cholesterol diet (HC), and the two HC diets containing 0.5% ergosterol (EL) and 1.5% ergosterol (EH), respectively, for 8 weeks. Results demonstrated that feeding EL and EH diets decreased serum total cholesterol (TC) by 19.4-21.6%, low density lipoproptein cholesterol (LDL-C) by 42.0-42.6%, and TC/HDL-C ratio by 7.1-10.5%. This was accompanied by 46.8-53.2% reduction in liver cholesterol and 51.0-59.3% increase in fecal cholesterol excretion with up-regulation on gene expression of liver sterol regulatory element-binding protein 2 (SREBP-2), low-density lipoprotein receptor (LDL-R) and Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (HMG-CoR). Results from micelles formation assay in vitro clearly demonstrated that ergosterol could significantly inhibit the entry of cholesterol into micelles. Therefore, the cholesterol-reducing effect of ergosterol was regulated by suppressing intestine cholesterol absorption and promoting the excretion of fecal cholesterol via modulating the expression of hepatic cholesterol-related genes.

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