数字农科院2.0

Spatiotemporal Expression Pattern Of Sjfz7 A.nd Its Expression Comparison W ith Other Frizzled Family Genes In Developmental Stages Of Schistosoma Japonicum

文献类型： 外文期刊

作者： Ye, ZX; Xu, JX; Feng, XG; Jia, YY; Fu, ZQ; Hong, Y; Li, H; Lu, K; Lin, JJ; Song, MX; Wang, LQ; Yuan, CX

作者机构：

关键词： Frizzled 7; Developmental stage; Schistosoma japonicum

期刊名称： GENE EXPRESSION PATTERNS

ISSN： 1567-133X

年卷期： 2019 年 32 卷

页码：

收录情况： JCR（2021版）

摘要： Wnts are secreted signaling molecules that are implicated in a variety of growth-related processes. Frizzled proteins have been identified as receptors for Wnt ligands in vertebrates and invertebrates, but a functional role for dioecious flatworm Frizzleds has not been determined. To evaluate the endogenous role of Frizzled proteins during development, we have identified and characterized a Schistosoma japonicum frizzled gene (Sjfz7). We found that Sjfz7 encodes a 698 amino acid protein with typical characteristics of Frizzled proteins. The immunohistochemical localization pattern showed that Sjfz7 protein was extensively distributed in almost all tissues of S. japonicum, including subtegumental muscle cells, parenchymal cells, intestinal epithelial cells and male and female germ cells. This indicated that Sjfz7-mediated Wnt signaling might be associated with the development of musculature, intestinal tract and reproductive organs in schistosome. Comparing mRNA levels between frizzled family members showed that Sjfz7 mRNA was consistently higher in the developmental stages analyzed, suggesting that Sjfz7 may be responsible for more functional tasks than other frizzled family members. Comparing frizzled mRNA levels between not fully developed and normal worms suggested that Wnt signaling might be abnormal in not fully developed worms.

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