数字农科院2.0

The Prominent Alteration In Transcriptome A.nd Metabolome Of Mycobacterium B ovis Bcg Str. Tokyo 172 Induced By Vitamin B-1

文献类型: 外文期刊

作者: Song, NN; Li, ZL; Cui, ZY; Chen, LP; Cui, YY; Dang, GH; Li, Z; Li, H; Liu, SG

作者机构:

关键词: Transcriptomics; Metabolomics; BCG; Vitamin B-1; Growth inhibition

期刊名称: BMC MICROBIOLOGY

ISSN: 1471-2180

年卷期: 2019 年 19 卷

页码:

收录情况: JCR(2021版)

摘要: Background: Vitamin B-1 (V-B1) is a crucial dietary nutrient and essential cofactor for several key enzymes in the regulation of cellular and metabolic processes, and more importantly in the activation of immune system. To date, the precise role of V-B1 in Mycobacterium tuberculosis remains to be fully understood. Results: In this study, the transcriptional and metabolic profiles of V-B1-treated Mycobacterium. bovis BCG were analyzed by RNA-sequencing and LC-MS (Liquid chromatography coupled to mass spectrometry). The selection of BCG strain was based on its common physiological features shared with M. tuberculosis. The results of cell growth assays demonstrated that V-B1 inhibited the BCG growth rate in vitro. Transcriptomic analysis revealed that the expression levels of genes related to fatty acid metabolism, cholesterol metabolism, glycolipid catabolism, DNA replication, protein translation, cell division and cell wall formation were significantly downregulated in M. bovis BCG treated with V-B1. In addition, the metabolomics LC-MS data indicated that most of the amino acids and adenosine diphosphate (ADP) were decreased in M. bovis BCG strain after V-B1 treatment. Conclusions: This study provides the molecular and metabolic bases to understand the impacts of V-B1 on M.bovis BCG.

分类号:

  • 相关文献

[1]Comparison of freshly squeezed, Non-thermally and thermally processed orange juice based on traditional quality characters, untargeted metabolomics, and volatile overview. Wang K., Xu Z.. 2022

[2]Salicylic acid inhibits gibberellin signaling through receptor interactions. Xiaodong Yu Xiaoyu Cui Chong Wu Shixi Shi Shunping Yan. 2022

[3]Safflomin A: A novel chemical marker for Carthamus tinctorius L. (Safflower) monofloral honey. Zhao L., Ren C., Xue X., Lu H., Wang K., Wu L.. 2022

[4]Natural plant toxins in honey: An ignored threat to human health. Yan S., Wang K., Al Naggar Y., Vander Heyden Y., Zhao L., Wu L., Xue X.. 2022

[5]Identifying Metabolic Perturbations And Toxic Effects Of Rac-Metalaxyl And Metalaxyl-M In Mice Using Integrative Nmr And Uplc-Ms/Ms Based Metabolomics. Wang, Sheng,He, Lin,Zhu, Wentao,Zhang, Ping,Zhang, Ping,Wang, Sheng,Xu, Yangyang,He, Yuhan,He, Yuhan,Yang, Furong,Yu, Weizhong,Shi, Dongmei,Xu, Yangyang,Zhang, Ping,Zhang, Ping,He, Lin,Zhang, Ping,Zhang, Ping,Yang, Furong,Yu, Weizhong,Shi, Dongmei,He, Yuhan,He, Lin. 2019

[6]Effects Of Pu-Erh Ripened Tea O.n Hyperuricemic Mice Studied B y Serum Metabolomics. Chen, Dong,Zhao, Ran,Zhao, Ran,Chen, Dong,Zhao, Ran,Wu, Hualing,Wu, Hualing. 2017

[7]Inositol As A New Enhancer For Improving Lipid Production And Accumulation In Schizochytrium Sp. Sr21. Wang, Jun,Sheng, Sheng,You, Shuai,Wu, Fu-An,Sheng, Sheng,Wang, Jun,Wu, Fu-An,Sheng, Sheng,You, Shuai,You, Shuai,Tang, Bin-Ping,Wang, Bo,Liu, Zhao-Xin,You, Shuai,Wang, Jun,Wang, Jun,Sheng, Sheng,Wu, Fu-An,Wu, Fu-An. 2019

[8]Integrated proteomics and metabolomics analysis of tea leaves fermented by Aspergillus niger, Aspergillus tamarii and Aspergillus fumigatus. Yan Ma,Tie-jun Ling,Xiao-qin Su,Bin Jiang,Bo Nian,Li-jiao Chen,Ming-li Liu,Zheng-yan Zhang,Dao-ping Wang,Yong-ying Mu,Wen-wen Jiao,Qian-ting Liu,Ying-hong Pan,Ming Zhao. 2021

[9]Washed Microbiota Transplantation Vs. Manual Fecal Microbiota Transplantation: Clinical Findings, Animal Studies And In Vitro Screening. Zhang, Faming,Yin, Haoran,Zhang, Faming,Zhang, Faming,Wang, Huiquan,Marcella, Cicilia,Lu, Gaochen,Shen, Quan,Marcella, Cicilia,Zhao, Zhe,Chen, Yaoyao,Zhang, Ting,Cheng, Lei,Chen, Yaoyao,Zhang, Ting,Cui, Bota,Li, Pan,Cheng, Lei,Cui, Bota,Lu, Gaochen,Ji, Guozhong,Ji, Guozhong,Liu, Yafei,Li, Pan,Liu, Yafei. 2020

[10]Effects Of Low-Levels Of Three H.exabromocyclododecane Diastereomers On The M etabolic Profiles Of Pak Choi Leaves Using High-Throughput Untargeted Metabolomics Approach. Guo, Qiqi,Liu, Xiaowei,Wang, Yuehua,He, Zeying,Tan, Dongfei,Zhang, Yanwei. 2018

[11]Evaluation Of The Metabolic Effects Of Hydrogen Sulfide On The Development Of Bombyx Mori (Lepidoptera: Bombycidae), Using Liquid Chromatography-Mass Spectrometry-Based Metabolomics. Wei, Zhao-Jun,Thakur, Kiran,Hu, Fei,Cao, Yu-Yao,Peng, Li-Li,Jiang, Li,Tang, Shun-Ming,Tang, Shun-Ming. 2020

[12]Perinatal Exposure To Low-Dose Decabromodiphenyl E.thane Increased The Risk O f Obesity In Male Mice Offspring. Yan, Jin,Yan, Sen,Wang, Dezhen,Meng, Zhiyuan,Li, Ruisheng,Jia, Ming,Tian, Sinuo,Zhang, Renke,Zhou, Zhiqiang,Zhu, Wentao,Teng, Miaomiao,Yao, Chenyang,Sheng, Jing. 2018

[13]Nutrient Reabsorption Mechanism Adapted to Low Phosphorus in Wild and Cultivated Soybean Varieties. Shen, Wenyue,Guo, Rui,Zhao, Yaxuan,Liu, Danping,Chen, Jing,Miao, Ningning,Gao, Shujuan,Zhang, Tao,Shi, Lianxuan. 2021

[14]The Antagonistic Effect Of Mycotoxins D.eoxynivalenol And Zearalenone On M etabolic Profiling In Serum And Liver Of Mice. Ji, J, Zhu, P, Cui, FC, Pi, FW, Zhang, YZ, Li, Y, Wang, JS, Sun, XL. 2017

[15]High-Throughput Non-Targeted Metabolomics Study Of The Effects Of Perfluorooctane Sulfonate (Pfos) On The Metabolic Characteristics Of A. Thaliana Leaves. Guo, QQ, He, ZY, Liu, XW, Liu, BJ, Zhang, YW. 2020

[16]Subacute Oral Toxicity Assessment Of B.enalaxyl In Mice Based O n Metabolomics Methods. Wang, XR, Wang, DZ, Zhou, ZQ, Zhu, WT. 2018

[17]Metabolomic Analysis Reveals The Composition D.ifferences In 13 Chinese T ea Cultivars Of Different Manufacturing Suitabilities. Li, PL, Dai, WD, Lu, ML, Xie, DC, Tan, JF, Yang, C, Zhu, Y, Lv, HP, Peng, QH, Zhang, Y, Guo, L, Ni, DJ, Lin, Z. 2018

[18]Lipidomes In Health And Disease: Analytical Strategies And Considerations. Wei, F, Lamichhane, S, Oresic, M, Hyotylainen, T. 2019

[19]Mycokey Round Table Discussions Of F.uture Directions In Research O n Chemical Detection Methods, Genetics And Biodiversity Of Mycotoxins. Leslie, JF, Lattanzio, V, Audenaert, K, Battilani, P, Cary, J, Chulze, SN, De Saeger, S, Gerardino, A, Karlovsky, P, Liao, YC, Maragos, CM, Meca, G, Medina, A, Moretti, A, Munkvold, G, Mule, G, Njobeh, P, Pecorelli, I, Perrone, G, Pietri, A, Palazzini, JM, Proctor, RH, Rahayu, ES, Ramirez, ML, Samson, R, Stroka, J, Sulyok, M, Sumarah, M, Waalwijk, C, Zhang, Q, Zhang, H, Logrieco, AF. 2018

[20]Postharvest Metabolomic Changes In Pyrus U.ssuriensis Maxim. Wild Accession ' Zaoshu Shanli'. Xu, JY, Zhang, Y, Qi, D, Huo, HL, Dong, XG, Tian, LM, Zhang, XS, Liu, C, Cao, YF. 2018

作者其他论文 更多>>