数字农科院2.0

Genome-Wide Association Study Of H/L T.raits In Chicken

文献类型： 外文期刊

作者： Zhu, B; Li, QH; Liu, RR; Zheng, MQ; Wen, J; Zhao, GP

作者机构：

关键词： chicken; heterophils; lymphocyte; GWAS; SNP

期刊名称： ANIMALS

ISSN： 2076-2615

年卷期： 2019 年 9 卷 5 期

页码：

收录情况： JCR（2021版）

摘要： Simple Summary With the continuous increase of intensive agriculture, the poultry industry has developed rapidly. Concurrently, diseases such as avian influenza, salmonella, and Newcastle disease have brought huge losses to the poultry industry. The traditional method of disease prevention and treatment includes vaccinations, but these have been linked to concerns associated with expense and meat safety. To solve these problems, genetic breeding methods can be used. In this paper, a genome-wide association analysis was linked to heterophil/lymphocyte ratio disease-resistance traits as a means through which disease damage can be mitigated. Abstract Presently, the heterophil-to-lymphocyte (H/L) ratio is being studied extensively as a disease resistance trait. Through intricate mechanisms to identify and destroy pathogenic microorganisms, heterophils play a pivotal role in the immune defense systems of avian species. To reveal the genetic basis and molecular mechanisms affecting the H/L ratio, phenotypic and H/L data from 1650 white feather chicken broilers were used in performing a genome-wide association study. A self-developed, chicken-specific 55K chip was used for heterophils, lymphocytes, and H/L classification, according to individual genomic DNA profiles. We identified five significant single nucleotide polymorphisms (SNPs) when the genome-wide significance threshold was set to 5% (p < 2.42 x 10(-6)). A total of 15 SNPs obtained seemingly significant levels (p < 4.84 x 10(-5)). Gene annotation indicated that CARD11 (Caspase recruitment domain family member 11), BRIX1 (Biogenesis of ribosomes BRX1), and BANP (BTG3 associated nuclear protein) play a role in H/L-associated cell regulation and potentially constitute candidate gene regions for cellular functions dependent on H/L ratios. These results lay the foundation for revealing the genetic basis of disease resistance and future marker-assisted selection for disease resistance.

分类号：

  • 相关文献

[1]Single Snp- And Pathway-Based Genome-Wide A.ssociation Studies For Beak D eformity In Chickens Using High-Density 600K Snp Arrays. Bai, H, Sun, YY, Liu, NA, Xue, FG, Li, YL, Xu, SS, Ye, JH, Zhang, L, Chen, Y, Chen, JL. 2018

[2]A New Chicken 55K Snp G.enotyping Array. Liu, RR, Xing, SY, Wang, J, Zheng, MQ, Cui, HX, Crooijmans, RPMA, Li, QH, Zhao, GP, Wen, J. 2019

[3]The Genetic Architecture Of The Chickens Dropping Moisture By Genetic Parameter Estimation And Genome-Wide Association. Zhu, T, Zhang, TY, Wen, JH, Zhao, XY, Chen, Y, Jia, YX, Wang, L, Lv, XZ, Yang, WF, Guan, Z, Ning, ZH, Qu, LJ. 2020

[4]Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum. . 2025

[5]噬菌体展示技术分析鸡贫血病毒VP1蛋白抗原结构特征. 王晓艳,高玉龙,高宏雷,付朝阳,邓小芸,林欢,祁小乐,王笑梅. 2007

[6]GlobalgeneexpressionprofileofchickenspleentissueatalaterstageofIBVinfectionrevealspathogenesisandimmunemechanisms. FengCong,ZongxiHan,FengjieWang,YuhaoShao,XiangangKong,ShengwangLiu. 2014

[7]EIAV基因转移载体启动子的比较. 韩凌霞,李亚明,曲连东,司昌德,姜骞,刘家森. 2006

[8]MGISEQ-2000、HiSeq 2000与NovaSeq 6000平台全基因组重测序数据的比较分析. 李伟宁,刘刚,周荣,唐中林,刘剑锋,孙飞舟. 2021

[9]水稻剑叶形态QTL定位及候选基因分析. 王盛,叶涵斐,李三峰,姜嘉骥,张月,潘晨阳,周维永,陈维娴,王珂欣,戴高兴,方媛,饶玉春,王跃星. 2021

[10]产茸相关SNP位点在7个梅花鹿群体中的验证. 田雪琪,李洋,刘汇涛,王天骄,邢秀梅. 2021

[11]Cytoprotective Effect Of Deferiprone Against A.luminum Chloride-Induced Oxidative Stress A nd Apoptosis In Lymphocytes. Zhuang, CC, She, Y, Zhang, HY, Song, M, Han, Y, Li, YF, Zhu, YZ. 2018

[12]Boron Affects Immune Function Through M.odulation Of Splenic T L ymphocyte Subsets, Cytokine Secretion, And Lymphocyte Proliferation And Apoptosis In Rats. Jin, EH, Li, SH, Ren, M, Hu, QQ, Gu, YF, Li, K. 2017

[13]Regional Association Analysis-Based Fine Mapping O.f Three Clustered Qtl F or Verticillium Wilt Resistance In Cotton (G. Hirsutum. L). Zhao, Yunlei,Wang, Hongmei,Zhao, Pei,Gong, Haiyan,Sang, Xiaohui,Chen, Wei,Cui, Yanli. 2017

[14]An Rna Sequencing Transcriptome Analysis O.f Grasspea (Lathyrus Sativus L .) And Development Of Ssr And Kasp Markers. Hu, Jinguo,Chang, Jianwu,Burlyaeva, Marina,Hao, Xiaopeng,Liu, Rong,Ren, Guixing,Wang, Dong,Wang, Yan,Yang, Tao,Yao, Yang,Zhang, Hongyan,Zong, Xuxiao. 2017

[15]Consensus Genetic Linkage Map Construction A.nd Qtl Mapping For P lant Height-Related Traits In Linseed Flax (Linum Usitatissimum L.). Zhang, Tianbao,Dang, Zhanhai,Dang, Zhao,Long, Yan,Wang, Liming,Song, Xiaxia,Pei, Xinwu,Zhang, Jianping. 2018

[16]Allelic Variations Of Endopolygalacturonase Genes A.ssociated With Fruit Softening I n Apricot (Prunus Armeniaca). Xu, M.,Wei, X.,Zhang, Q. P.,Zhang, Y. J.,Zhang, Y. P.,Ma, X. X.,Liu, N.,Liu, S.,Liu, W. S.. 2018

[17]Development Of Molecular Markers Linked T.o Powdery Mildew Resistance G ene Pm4B By Combining Snp Discovery From Transcriptome Sequencing Data With Bulked Segregant Analysis (Bsr-Seq) In Wheat. Wu, PP, Xie, JZ, Hu, JH, Qiu, D, Liu, ZY, Li, JT, Li, MM, Zhang, HJ, Yang, L, Liu, HW, Zhou, Y, Zhang, ZJ, Li, HJ. 2018

[18]Waxy Allelic Diversity In Common M.illet (Panicum Miliaceum L.) I n China. Wang, RY, Wang, HG, Liu, XH, Ji, X, Chen, L, Lu, P, Liu, MX, ZhijunQiaob, B, Qiao, ZJ. 2018

[19]Construction Of Genetic Linkage Map U.sing Genotyping-By-Sequencing And Identification O f Qtls Associated With Leaf Color In Spinach. Cai, XF, Xu, CX, Wang, XL, Wang, S, Zhang, ZH, Fei, ZJ, Wang, QH. 2018

[20]Identification Of A Major Qtl F.or Seed Number Per S ilique In Cabbage (Brassica Oleracea L. Var. Capitata) Using Genotyping By Sequencing. Li, X, Kong, CC, Yu, HL, Liu, XP, Fang, ZY, Liu, YM, Yang, LM, Zhuang, M, Wang, Y, Lv, HH, Zhang, YY. 2019

作者其他论文 更多>>