数字农科院2.0

Efficacy Of Antiretroviral Compounds Against Toxoplasma Gondii In Vitro

文献类型： 外文期刊

作者： Wang, JL; Elsheikha, HM; Li, TT; He, JJ; Bai, MJ; Liang, QL; Zhu, XQ; Cong, W

作者机构：

关键词： Toxoplasma Gondii; Antiretroviral Compounds; Cerebral Toxoplasmosis; Drug Repurposing; Hiv; Aids

期刊名称： INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

ISSN： 0924-8579

年卷期： 2019 年 54 卷 6 期

页码：

收录情况： JCR（2021版）

摘要： The obligate intracellular parasite Toxoplasma gondii can infect nearly all warm-blooded animals, including humans. Although infection with this parasite is generally benign, severe illness may occur in infected individuals if their immunity becomes less competent, such as in human immunodeficiency virus (HIV)-infected patients. In this study, the inhibitory activity of 44 commonly used antiretroviral compounds was determined against T. gondii in vitro. Of the 44 tested antiretroviral compounds, 14 showed potency against T. gondii at IC50 concentrations (concentration inhibiting T. gondii tachyzoite growth by 50%) ranging from 1.18 +/- 2.21 mu M (nelfinavir) to 18.89 +/- 1.87 mu M (trovirdine). Of the 14 potent antiretroviral compounds, 7 are HIV-1 protease inhibitors. This study also investigated whether co-administration of these 14 antiretroviral compounds interferes with the anti-T. gondii activity of existing anti-T. gondii drugs, namely sulfadiazine and pyrimethamine. The results showed no significant interaction between any of the 14 tested antiretroviral compounds and pyrimethamine or sulfadiazine. These results warrant investigation of whether administration of the lead antiretroviral drugs with highly potent anti-T. gondii activity to HIV patients may help to limit the occurrence of toxoplasmic encephalitis. (C) 2019 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

分类号：

  • 相关文献

[1]Differential Brain Microrna Expression Profiles A.fter Acute And Chronic I nfection Of Mice With Toxoplasma Gondii Oocysts. Hu, RS, He, JJ, Elsheikha, HM, Zhang, FK, Zou, Y, Zhao, GH, Cong, W, Zhu, XQ. 2018

[2]MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation. 于长清,,李苏楠,,张险峰,,王钰. 2020

[3]Attenuation Of Equine Lentivirus Alters M.itochondrial Protein Expression Profile F rom Inflammation To Apoptosis. Du, C, Duan, YY, Wang, XF, Lin, YZ, Na, L, Wang, XH, Chen, KW, Wang, XJ. 2019

[4]microRNA-21: a key modulator in oncogenic viral infections. Guitian He,Juntao Ding,Yong’e Zhang,Mengting Cai,Jing Yang,William C. Shing Cho,Yadong Zheng. 2021

[5]First Report of Toxoplasma gondii Seroprevalence in Pet Parrots in China. Zhang, Xiao-Xuan,Zhang, Nian-Zhang,Tian, Wei-Peng,Zhou, Dong-Hui,Zhu, Xing-Quan,Zhang, Xiao-Xuan,Xu, Ying-Tian,Tian, Wei-Peng. 2014

[6]Impact of environmental factors on the emergence, transmission and distribution of Toxoplasma gondii. Yan, Chao,Liang, Li-Jun,Zheng, Kui-Yang,Zhu, Xing-Quan,Yan, Chao,Zhu, Xing-Quan,Liang, Li-Jun,Zhu, Xing-Quan. 2016

[7]Genetic Diversity of Toxoplasma gondii Strains from Different Hosts and Geographical Regions by Sequence Analysis of GRA20 Gene. Ning, Hong-Rui,Xu, Qian-Ming,Zhu, Xing-Quan,Ning, Hong-Rui,Huang, Si-Yang,Wang, Jin-Lei,Zhu, Xing-Quan. 2015

[8]Geographical patterns of Toxoplasma gondii genetic diversity revealed by multilocus PCR-RFLP genotyping. Shwab, E. Keats,Majumdar, Debashree,Su, Chunlei,Zhu, Xing-Quan,Su, Chunlei,Pena, Hilda F. J.,Gennari, Solange M.,Dubey, Jitender P.. 2014

[9]Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection. He, Jun-Jun,Ma, Jun,Wang, Jin-Lei,Xu, Min-Jun,Zhu, Xing-Quan,Ma, Jun,Xu, Min-Jun,Zhu, Xing-Quan.

[10]Vaccination with Toxoplasma gondii calcium-dependent protein kinase 6 and rhoptry protein 18 encapsulated in poly(lactide-co-glycolide) microspheres induces long-term protective immunity in mice. Zhang, Nian-Zhang,Xu, Ying,Wang, Meng,Chen, Jia,Huang, Si-Yang,Zhu, Xing-Quan,Xu, Ying,Gao, Qi,Huang, Si-Yang,Zhu, Xing-Quan. 2016

[11]Molecular detection and genotypic characterization of Toxoplasma gondii infection in bats in four provinces of China. Qin, Si-Yuan,Cong, Wei,Zhang, Fu-Kai,Huang, Si-Yang,Zhu, Xing-Quan,Liu, Ye,Li, Nan,Wang, Ze-Dong,Liu, Quan,Qin, Si-Yuan,Cong, Wei,Zhu, Xing-Quan,Zhu, Xing-Quan. 2014

[12]Evaluation of recombinant granule antigens GRA1 and GRA7 for serodiagnosis of Toxoplasma gondii infection in dogs. Wang, Zedong,Huang, Si-Yang,Zhu, Xing-Quan,Wang, Zedong,Ge, Wei,Li, Jiping,Liu, Quan. 2014

[13]Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model. Yuan, Zi-Guo,Ren, Di,Zhou, Dong-Hui,Zhou, Yang,Zhu, Xing-Quan,Yuan, Zi-Guo,Ren, Di,Zhang, Xiu-Xiang,Li, Xiu-Zhen,Petersen, Eskild,Petersen, Eskild,Yang, Gui-Lian,Zhu, Xing-Quan. 2013

[14]Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3. Zhang, Nian-Zhang,Huang, Si-Yang,Zhou, Dong-Hui,Chen, Jia,Zhu, Xing-Quan,Xu, Ying,Zhu, Xing-Quan,Tian, Wei-Peng,Lu, Jing,Zhu, Xing-Quan. 2013

[15]Toxoplasma gondii infection and schizophrenia: an inter-kingdom communication perspective. Elsheikha, Hany M.,Zhu, Xing-Quan.

[16]Seroprevalence and genotypes of Toxoplasma gondii isolated from pigs intended for human consumption in Liaoning province, northeastern China. Wang, Dawei,Zhang, Guoxin,Yuan, Gaoming,He, Jianbin,Yang, Na,Liu, Yan,Jiang, Tiantian,Su, Chunlei. 2016

[17]Seroprevalence and Risk Factors of Toxoplasma gondii Infection in Farmed Minks (Neovison vison) in Northeastern and Eastern China. Zheng, Wen-Bin,Cong, Wei,Ma, Jian-Gang,Wang, Chun-Feng,Qian, Ai-Dong,Zheng, Wen-Bin,Cong, Wei,Ma, Jian-Gang,Zhu, Xing-Quan,Meng, Qing-Feng,Zhu, Xing-Quan. 2016

[18]DNA vaccination with genes encoding Toxoplasma gondii antigens ROP5 and GRA15 induces protective immunity against toxoplasmosis in Kunming mice. Chen, Jia,Li, Zhong-Yuan,Huang, Si-Yang,Zhou, Dong-Hui,Zhu, Xing-Quan,Li, Zhong-Yuan,Zhu, Xing-Quan,Petersen, Eskild,Zhu, Xing-Quan. 2015

[19]The Ultrastructural Effects of Sulfachloropyrazine on Toxoplasma gondii Tachyzoites. Zeng, Y. B.,Dong, H.,Han, H. Y.,Jiang, L. L.,Zhao, Q. P.,Zhu, S. H.,Ma, W. J.,Cheng, J.,Huang, B.. 2013

[20]Determination of stage interconversion in vitro and in vivo by construction of transgenic Toxoplasma gondii that stably express stage-specific fluorescent proteins. Zhang, Houshuang,Zhang, Yanlei,Cao, Jie,Zhou, Yongzhi,Wang, Na,Zhou, Jinlin. 2013

作者其他论文 更多>>