数字农科院2.0

Ochratoxin A Induces Liver Inflammation: Involvement Of Intestinal Microbiota

文献类型： 外文期刊

作者： Wang, WC; Zhai, SS; Xia, YY; Wang, H; Ruan, D; Zhou, T; Zhu, YW; Zhang, HF; Zhang, MH; Ye, H; Ren, WK; Yang, L

作者机构：

关键词： Ochratoxin A; Intestinal Microbiota; Lps; Liver Inflammation; Fecal Microbiota Transplantation

期刊名称： MICROBIOME

ISSN： 2049-2618

年卷期： 2019 年 7 卷 1 期

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收录情况： JCR（2021版）

摘要： Background Ochratoxin A (OTA) is a widespread mycotoxin and induces liver inflammation to human and various species of animals. The intestinal microbiota has critical importance in liver inflammation; however, it remains to know whether intestinal microbiota mediates the liver inflammation induced by OTA. Here, we treated ducklings with oral gavage of OTA (235 mu g/kg body weight) for 2 weeks. Then, the microbiota in the cecum and liver were analyzed with 16S rRNA sequencing, and the inflammation in the liver was analyzed. To explore the role of intestinal microbiota in OTA-induced liver inflammation, intestinal microbiota was cleared with antibiotics and fecal microbiota transplantation was conducted. Results Here, we find that OTA treatment in ducks altered the intestinal microbiota composition and structure [e.g., increasing the relative abundance of lipopolysaccharides (LPS)-producing Bacteroides], and induced the accumulation of LPS and inflammation in the liver. Intriguingly, in antibiotic-treated ducks, OTA failed to induce these alterations in the liver. Notably, with the fecal microbiota transplantation (FMT) program, in which ducks were colonized with intestinal microbiota from control or OTA-treated ducks, we elucidated the involvement of intestinal microbiota, especially Bacteroides, in liver inflammation induced by OTA. Conclusions These results highlight the role of gut microbiota in OTA-induced liver inflammation and open a new window for novel preventative or therapeutic intervention for mycotoxicosis.

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