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Mirna-Seq Of Echinococcus Multilocularis Extracellular Vesicles And Immunomodulatory Effects Of Mir-4989

文献类型： 外文期刊

作者： Ding, JT; He, GT; Wu, JE; Yang, J; Guo, XL; Yang, X; Wang, Y; Kandil, OM; Kutyrev, I; Ayaz, M; Zheng, YD

作者机构：

关键词： Echinococcus Multilocularis; Emu-Mir-4989-3P; Extracellular Vesicles; Macrophage; Mirna

期刊名称： FRONTIERS IN MICROBIOLOGY

ISSN： 1664-302X

年卷期： 2019 年 10 卷

页码：

收录情况： JCR（2021版）

摘要： Alveolar echinococcosis caused by Echinococcus multilocularis is an important zoonotic disease. In the infected mice, emu-miR-4989-3p is present in sera, but its role remains unknown. Using high-throughput sequencing and qPCR, emu-miR-4989-3p was herein confirmed to be encapsulated into E. multilocularis extracellular vesicles. In the transfected macrophages, emu-miR-4989-3p was demonstrated to significantly inhibit NO production compared to the control (p < 0.05). Moreover, transfection of emu-miR-4989-3p also gave rise to the increased expression of TNF-alpha (p < 0.01). Furthermore, emu-miR-4989-3p induced the dysregulation of several key components in the LPS/TLR4 signaling pathway compared with the control, especially TLR4 and NF-kappa B that both were upregulated. Conversely, the NO production and the expression of TNF-alpha, TLR4 and NF-kappa B tended to be increased and decreased in the mimics-transfected cells upon emu-miR-4989-3p low expression, respectively. These results suggest that emu-miR-4989-3p is one of 'virulence' factors encapsulated into the extracellular vesicles, potentially playing a role in the pathogenesis of E. multilocularis.

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