数字农科院2.0

High Azole Resistance In Aspergillus Fumigatus Isolates From Strawberry Fields, China, 2018

文献类型： 外文期刊

作者： Chen, Y; Dong, FS; Zhao, JY; Fan, H; Qin, CP; Li, RA; Verweij, PE; Zheng, YQ; Han, L

作者机构：

期刊名称： EMERGING INFECTIOUS DISEASES

ISSN： 1080-6040

年卷期： 2020 年 26 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： In 2018, we conducted a cross-sectional study to investigate azole resistance in environmental Aspergillus fumigatus isolates obtained from different agricultural fields in China. Using 63 soil cores, we cultured for azole-resistant A. fumigatus and characterized isolates by their cyp51A gene type, short tandem repeat genotype, and mating type. Of 206 A. fumigatus isolates, 21 (10.2%) were azole resistant. Nineteen of 21 had mutations in their cyp51A gene (5 TR34/L98H, 8 TR34/L98H/S297T/F495I, 6 TR46/Y121F/T289A). Eighteen were cultured from soil samples acquired from strawberry fields, suggesting this soil type is a potential hotspot for azole resistance selection. Twenty resistant isolates were mating type MAT1-1, suggesting asexual sporulation contributed to their evolution. Prochloraz, difenoconazole, and tebuconazole were the most frequently detected fungicides in soil samples with azole-resistant fungus. Our study results suggest that managing the fungicides used in agriculture will help contain the problem of antifungal drug resistance in clinics.

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