数字农科院2.0

Effects Of Oral Monosodium Glutamate Administration On Serum Metabolomics Of Suckling Piglets

文献类型： 外文期刊

作者： Wang, ZB; Zhang, J; Wu, P; Luo, SY; Li, JZ; Wang, QY; Huang, PF; Li, YL; Ding, XQ; Hou, ZP; Wu, DQ; Huang, J; Tu, Q; Yang, HS

作者机构：

关键词： Metabolomics; Monosodium Glutamate; Nuclear Magnetic Resonance Spectroscopy; Serum; Suckling Piglets

期刊名称： JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

ISSN： 0931-2439

年卷期： 2020 年 104 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： This study was conducted to determine the effects of oral administration with glutamate on metabolism of suckling piglets based on H-1-Nuclear magnetic resonance (H-1 NMR) spectroscopy through the level of metabolism. Forty-eight healthy [(Yorkshire x Landrace) x Duroc] piglets born on the same day with a similar birth bodyweight (1.55 +/- 0.20 kg) were obtained from six sows (8 piglets per sow). The piglets from each sow were randomly assigned into four treatments (2 piglets per treatment). The piglets were given 0.09 g/kg body weight (BW) of sodium chloride (CN group), 0.03 g/kg BW monosodium glutamate (LMG group), 0.25 g/kg BW monosodium glutamate (MMG group) and 0.50 g/kg BW monosodium glutamate (HMG group) twice a day respectively. An H-1 NMR-based metabolomics' study found that the addition of monosodium glutamate (MSG) significantly reduced serum citrate content in 7-day-old piglets, while HMG significantly increased serum trimethylamine content and significantly reduced unsaturated fat content in 7-day-old piglets (p < .05). The content of glutamine, trimethylamine, albumin, choline and urea nitrogen was significantly increased and the creatinine content decreased significantly in the 21-day-old HMG (p < .05). Analysis of serum hormones revealed that glucagon-like peptide-1 (GLP-1) content in the 21-day-old HMG was highest (p < .05). The cholecystokinin (CCK) content in the HMG of 7-day-old piglets was lower than that in the LMG (p < .05), and the CCK content in the serum of the 21-day-old MMG was highest (p < .05). The serum leptin levels in the 21-day-old HMG were the lowest (p < .05). The serum insulin content in the 7-day-old MMG was highest (p < .05). This study suggests that MSG plays an important role in the metabolism of sugar, fat and protein (amino acids). These results provide a theoretical basis for designing piglet feed formulations.

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