数字农科院2.0

Identification Of Two Novel Prenylated Flavonoids In Mulberry Leaf And Their Bioactivities

文献类型： 外文期刊

作者： Yang, Bao;Tu, Jiaming;Yang, Bao;Wen, Lingrong;He, Mingyang;Jiang, Yueming;Wen, Lingrong;Jiang, Yueming;Shi, Dingding;Zhou, Ting;Tu, Jiaming;Zhou, Ting;Yang, Bao;He, Mingyang;Jiang, Yueming;Shi, Dingding;Wen, Lingrong

作者机构：

关键词： Prenylated Flavonoid; Morus Alba; Antioxidant Activity; Bioactivity; Nmr

期刊名称： FOOD CHEMISTRY

ISSN： 0308-8146

年卷期： 2020 年 315 卷

页码：

摘要： Mulberry leaf is a vegetable used in daily diet. It can bring delicious taste and multiple health benefits. However, the chemicals responsible for these health benefits remain unveiled. In this work, two novel prenylated flavonoids were isolated from mulberry leaf. Their structures were identified and named as morachalcone D and morachalcone E. The protective effects of these two compounds were investigated, against endogenous oxidative damage (oxytosis/ferroptosis) induced by glutamate and erastin in HT22 cells. The results revealed that morachalcone D was much more potent in preventing from glutamate- and erastin-induced cell death than morachalcone E. The neuroprotective effect of morachalcone D was related to the prevention of ROS production, glutathione depletion, and iron accumulation. Morachalcone D upregulated the expression of genes involved in antioxidant defense, including GPx4, CAT, SOD2, Nrf2, HMOX1 and SLC7A11. These findings indicated that morachalcone D was responsible for the health benefits of mulberry leaf, and could be a potent neuroprotective agent for use in dietary supplements and functional foods.

分类号：

  • 相关文献

[1]Purification of Total RNAs and Small RNAs from Fruit Tree Leaf Tissues. Ma Y., Li S.. 2022

[2]A H-1 Nmr Based Study O.f Hemolymph Metabonomics In D ifferent Resistant Silkworms, Bombyx Mori (Lepidotera), After Bmnpv Inoculation. Shao, Zuo:min,Wang, Xue:yang,Wu, Yang:chun,Wu, Yang:chun,Zhang, Ying:jian,Wang, Xue:yang,Deng, Ming:jie,Thi Thuy Vu,Xu, Jia:ping,Xu, Jia:ping. 2019

[3]Identifying Metabolic Perturbations And Toxic Effects Of Rac-Metalaxyl And Metalaxyl-M In Mice Using Integrative Nmr And Uplc-Ms/Ms Based Metabolomics. Wang, Sheng,He, Lin,Zhu, Wentao,Zhang, Ping,Zhang, Ping,Wang, Sheng,Xu, Yangyang,He, Yuhan,He, Yuhan,Yang, Furong,Yu, Weizhong,Shi, Dongmei,Xu, Yangyang,Zhang, Ping,Zhang, Ping,He, Lin,Zhang, Ping,Zhang, Ping,Yang, Furong,Yu, Weizhong,Shi, Dongmei,He, Yuhan,He, Lin. 2019

[4]Geographical Origin Discrimination Of Oolong T.ea (Tieguanyin, Camellia Sinensis ( L.) O. Kuntze) Using Proton Nuclear Magnetic Resonance Spectroscopy And Near-Infrared Spectroscopy. Cheng, Kian-Kai,Dong, Jiyang,Meng, Weijun,Shen, Guiping,Wu, Zhidan,Xu, Jingjing,Xu, Xiangnan. 2017

[5]The Application Of Nmr-Based Milk M.etabolite Analysis In Milk A uthenticity Identification. Li, QQ, Yu, ZB, Zhu, D, Meng, XH, Pang, XM, Liu, Y, Frew, R, Chen, H, Chen, G. 2017

[6]Detection Of Adulteration In Chinese Monofloral Honey Using H-1 Nuclear Magnetic Resonance And Chemometrics. Song, XY, She, S, Xin, MM, Chen, L, Li, Y, Vander Heyden, Y, Rogers, KM, Chen, LZ. 2020

[7]Pullulan Production From Synthetic Medium B.y A New Mutant O f Aureobasidium Pullulans. Chen, GQ, Wang, JM, Su, YL, Zhu, YS, Zhang, G, Zhao, HW, Liu, HB, Yang, Y, Nian, R, Zhang, HB, Wei, YX, Xian, M. 2017

[8]Toxoplasma Gondii Immune Mapped Protein 1. Is Anchored To T he Inner Leaflet Of The Plasma Membrane And Adopts A Novel Protein Fold. Jia, YG, Benjamin, S, Liu, Q, Xu, YQ, Dogga, SK, Liu, J, Matthews, S, Soldati-Favre, D. 2017

[9]Metabolomic Analysis Of Alterations In L.ipid Oxidation, Carbohydrate And A mino Acid Metabolism In Dairy Goats Caused By Exposure To Aflotoxin B1. Cheng, JB, Huang, S, Fan, CY, Zheng, N, Zhang, YD, Li, SL, Wang, JQ. 2017

[10]New malonylginsenosides from the fresh fruits of Panax notoginseng. Zheng-Yi Qu,Yu Zong,Pei-He Zheng,Yin-Ping Jin,Wei Li,He-Cheng Wang,Ya-Li Li,Ying-Ping Wang. 2021

[11]Synthesis And Bioactivity Studies Of S.ex Pheromone Analogs Of T he Diamond Back Moth, Plutella Xylostella. Wang, Liu-yang,Weng, Ai-zhen,Zhang, Kai-Xin,Zhang, Kai-Xin,Zhang, Yun-hui,She, Dong-mei,Mei, Xiang-dong,Wang, An-jia,Zhang, Zhi,Ning, Jun,Gao, Yu-lin. 2019

[12]Morphological Characteristics, Nutrients, And Bioactive C.ompounds Of Zizania Latifolia, A nd Health Benefits Of Its Seeds. Yan, N, Du, YM, Liu, XM, Chu, C, Shi, J, Zhang, HB, Liu, YH, Zhang, ZF. 2018

[13]Epigallocatechin Gallate-Beta-Lactoglobulin Nanoparticles Improve The A.ntitumor Activity Of Egcg F or Inducing Cancer Cell Apoptosis. Wu, M, Jin, JC, Jin, P, Xu, YQ, Yin, JF, Qin, DK, Wang, K, Du, QZ. 2017

[14]Sulfonate-Functionalized Mesoporous Silica Nanoparticles As C.arriers For Controlled Herbicide D iquat Dibromide Release Through Electrostatic Interaction. Huang, Qiliang,Li, Fengmin,Huang, Qiliang,Zhao, Pengyue,Cao, Chong,Cao, Lidong,Cao, Lidong,Xu, Chunli,Xu, Bo,Shan, Yongpan. 2019

[15]Development of RS-pyrisoxazole for reduction of pesticide inputs: A new insight from systemic evaluation of pyrisoxazole at the stereoisomeric level. Xinglu Pan,Fengshou Dong,Na Liu,Jun Xu,Xingang Liu,Xiaohu Wu,Yongquan Zheng. 2021

[16]Dual-Functionalized Pesticide Nanocapsule Delivery System With Improved Spreading Behavior And Enhanced Bioactivity. Cui, JX, Sun, CJ, Wang, AQ, Wang, Y, Zhu, HX, Shen, Y, Li, NJ, Zhao, X, Cui, B, Wang, C, Gao, F, Zeng, ZH, Cui, HX. 2020

[17]Safflomin A: A novel chemical marker for Carthamus tinctorius L. (Safflower) monofloral honey. Zhao L., Ren C., Xue X., Lu H., Wang K., Wu L.. 2022

[18]Effects of partial substitution of chemical fertilizer with biogas slurry on nitrous oxide emissions and the related nitrifier and denitrifier in a saline–alkali soil. Shi Y., Rahaman M.A., Zhang Q., Zhan X., Zheng L.. 2022

[19]Characterization Of A Novel Interleukin-1 Receptor Antagonist From Sheep (Ovis Aries). Zhang, SJ, Guo, X, Hu, P, Lu, SY, Liu, NN, Fu, BQ, Wang, N, Li, YS, Wang, LL, Chang, J, Chang, HZ, Liu, ZS, Zhou, Y, Ren, HL. 2020

[20]Bioactivities And Medicinal Value Of S.olanesol And Its Accumulation, E xtraction Technology, And Determination Methods. Yan, N, Liu, YH, Liu, LQ, Du, YM, Liu, XM, Zhang, HB, Zhang, ZF. 2019

作者其他论文 更多>>