数字农科院2.0

Long Noncoding Rnas: New Insights In Modulating Mammalian Spermatogenesis

文献类型： 外文期刊

作者： Sahlu, BW; Zhao, SJ; Wang, XG; Umer, S; Zou, HY; Huang, JM; Zhu, HB

作者机构：

关键词： Germ Cell; Long Noncoding Rna; Mammalian Spermatogenesis; Regulatory Pathways; Spermatocytes

期刊名称： JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY

ISSN： 2049-1891

年卷期： 2020 年 11 卷 1 期

页码：

收录情况： SCI

摘要： Spermatogenesis is a complex differentiating developmental process in which undifferentiated spermatogonial germ cells differentiate into spermatocytes, spermatids, and finally, to mature spermatozoa. This multistage developmental process of spermatogenesis involves the expression of many male germ cell-specific long noncoding RNAs (lncRNAs) and highly regulated and specific gene expression. LncRNAs are a recently discovered large class of noncoding cellular transcripts that are still relatively unexplored. Only a few of them have post-meiotic; however, lncRNAs are involved in many cellular biological processes. The expression of lncRNAs is biologically relevant in the highly dynamic and complex program of spermatogenesis and has become a research focus in recent genome studies. This review considers the important roles and novel regulatory functions whereby lncRNAs modulate mammalian spermatogenesis.

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