数字农科院2.0

Viral Pathogenesis, Recombinant Vaccines, And Oncolytic Virotherapy: Applications Of The Canine Distemper Virus Reverse Genetics System

文献类型： 外文期刊

作者： Zhao, JJ; Ren, YR; Chen, J; Zheng, JS; Sun, DB

作者机构：

关键词： canine distemper virus; reverse genetic system; pathogenesis; recombinant vaccine; virotherapy

期刊名称： VIRUSES-BASEL

ISSN：

年卷期： 2020 年 12 卷 3 期

页码：

收录情况： JCR（2021版）

摘要： Canine distemper virus (CDV) is a highly contagious pathogen transmissible to a broad range of terrestrial and aquatic carnivores. Despite the availability of attenuated vaccines against CDV, the virus remains responsible for outbreaks of canine distemper (CD) with significant morbidity and mortality in domesticated and wild carnivores worldwide. CDV uses the signaling lymphocytic activation molecule (SLAM, or CD150) and nectin-4 (PVRL4) as entry receptors, well-known tumor-associated markers for several lymphadenomas and adenocarcinomas, which are also responsible for the lysis of tumor cells and apparent tumor regression. Thus, CDV vaccine strains have emerged as a promising platform of oncolytic viruses for use in animal cancer therapy. Recent advances have revealed that use of the CDV reverse genetic system (RGS) has helped increase the understanding of viral pathogenesis and explore the development of recombinant CDV vaccines. In addition, genetic engineering of CDV based on RGS approaches also has the potential of enhancing oncolytic activity and selectively targeting tumors. Here, we reviewed the host tropism and pathogenesis of CDV, and current development of recombinant CDV-based vaccines as well as their use as oncolytic viruses against cancers.

分类号：

  • 相关文献

[1]Construction and identification of an infectious clone for CDV-3 strain of canine distemper virus [犬瘟热病毒CDV-3株感染性克隆的构建与鉴定]. Bu Y.,Yan X.,Zhao J.,Li H.,Zhao C.,Xue X.. 2021

[2]Comparative Evaluation Of Three Capripoxvirus-Vectored P.este Des Petits Ruminants V accines. Fakri, F, Bamouh, Z, Ghzal, F, Baha, W, Tadlaoui, K, Fihri, OF, Chen, W, Bu, Z, Elharrak, M. 2018

[3]A rabies virus vectored severe fever with thrombocytopenia syndrome (SFTS) bivalent candidate vaccine confers protective immune responses in mice. Tian Li,Yan Lina,Zheng Wenwen,Lei Xiaoying,Fu Qianyun,Xue Xianghong,Wang Xianwei,Xia Xianzhu,Zheng Xuexing. 2021

[4]Characterization And Pathogenicity Of Fowl Adenovirus Serotype 4 Isolated From Eastern China. Sun, Haiwei,Chen, Hongjun,Li, Yunzhang,Wang, Kai,Ye, Jianqiang,Yang, Zhiwei. 2019

[5]Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination. Hossain, Md Golzar,Tang, Yan-dong,Akter, Sharmin,Zheng, Chunfu. 2021

[6]Sialidases From Clostridium Perfringens And Their Inhibitors. Wang, YH. 2020

[7]Disruption Of Ossec3A Increases The C.ontent Of Salicylic Acid A nd Induces Plant Defense Responses In Rice. Ma, J, Chen, J, Wang, M, Ren, YL, Wang, S, Lei, CL, Cheng, ZJ, Sodmergen. 2018

[8]Identification Of Novel Genes Essential F.or Brucella Abortus To E stablish Infection By Signature-Tagged Mutagenesis. Tian, MX, Qu, J, Li, P, Bao, YQ, Liu, JM, Ding, C, Wang, SH, Li, T, Qi, JJ, Yu, SQ. 2019

[9]Identification Of Genes Involved In M.ycoplasma Gallisepticum Biofilm Formation U sing Mini-Tn4001-Sgm Transposon Mutagenesis. Wang, Y, Yi, L, Zhang, FQ, Qiu, XS, Tan, L, Yu, SQ, Cheng, XC, Ding, C. 2017

[10]Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus. Abdul Wahaab,Ke Liu,Muddassar Hameed,Muhammad Naveed Anwar,Lei Kang,Chenxi Li,Xiaochun Ma,Abdul Wajid,Yi Yang,Umair Hassan Khan,Jianchao Wei,Beibei Li,Donghua Shao,Yafeng Qiu,Zhiyong Ma. 2021

[11]Genomic sequence resource of Kabatiella zeae, the causative pathogen of corn eyespot disease. Wang Y.,Yao J.,Xia X.,Li Z.,Zhou S.,Liu W.,Wu H.. 2021

[12]Isolation And Sequence Analysis Of T.he Complete Vp2 Gene O f Canine Parvovirus From Chinese Domestic Pets And Determination Of The Pathogenesis Of These Circulating Strains In Beagles. Chen, MR, Guo, XY, Wang, ZY, Jiang, YT, Yuan, WF, Xin, T, Hou, SH, Song, TQ, Lin, WD, Zhu, HF, Jia, H. 2019

[13]Porcine Reproductive And Respiratory Syndrome V.irus Infection Of Bone M arrow: Lesions And Pathogenesis. Wang, G, Yu, Y, He, XJ, Wang, MH, Cai, XH, Zimmerman, JJ. 2019

[14]Myh9 Key Amino Acid Residues Identified By The Anti-Idiotypic Antibody To Porcine Reproductive And Respiratory Syndrome Virus Glycoprotein 5 Involve In The Virus Internalization By Porcine Alveolar Macrophages. Li, LL, Zhang, L, Hu, QF, Zhao, L, Nan, YC, Hou, GP, Chen, YY, Han, XM, Ren, XL, Zhao, Q, Tao, H, Sun, ZZ, Zhang, GP, Wu, CY, Wang, JF, Zhou, EM. 2020

[15]Picornavirus 3C – a protease ensuring virus replication and subverting host responses. Jiamin Yi,Jiangling Peng,Wenping Yang,Guoqiang Zhu,Jingjing Ren,Dan Li,Haixue Zheng. 2021

[16]Evolutionary Dynamics And Age-Dependent Pathogenesis Of Sub-Genotype Vi.2.1.1.2.2 Ppmv-1 In Pigeons. Xie, P, Chen, LB, Zhang, YF, Lin, QY, Ding, C, Liao, M, Xu, CG, Xiang, B, Ren, T. 2020

[17]Roles of the polybasic furin cleavage site of spike protein in SARS-CoV-2 replication, pathogenesis, and host immune responses and vaccination. Hossain, Md Golzar,Tang, Yan-dong,Akter, Sharmin,Zheng, Chunfu. 2022

[18]Virus–Host Interactions in Foot-and-Mouth Disease Virus Infection. Kangli Li,Congcong Wang,Fan Yang,Weijun Cao,Zixiang Zhu,Haixue Zheng. 2021

[19]UvWHI2 is Required for Stress Response and Pathogenicity in Ustilaginonidea virens. Shuai Meng, Jiehua Qiu1, Meng Xiong, Zhiquan Liu, Jane Sadhna Jagernath, Fucheng Lin, Huanbin Shi1, Yanjun Kou. 2021

[20]Swine Acute Diarrhea Syndrome Coronavirus-Induced Apoptosis Is Caspase- And Cyclophilin D- Dependent. Zhang, JY, Han, YR, Shi, HY, Chen, JF, Zhang, X, Wang, XB, Zhou, L, Liu, JB, Zhang, JL, Ji, ZY, Jing, ZY, Ma, JY, Shi, D, Feng, L. 2020

作者其他论文 更多>>