数字农科院2.0

Avermectin Loaded Carboxymethyl Cellulose Nanoparticles With Stimuli-Responsive And Controlled Release Properties

文献类型： 外文期刊

作者： Zhu, HX; Shen, Y; Cui, JX; Wang, AQ; Li, NJ; Wang, C; Cui, B; Sun, CJ; Zhao, X; Wang, CX; Gao, F; Zhan, SS; Guo, L; Zhang, L; Zeng, ZH; Wang, Y; Cui, HX

作者机构：

关键词： Avermectin; Esterase-Responsive; Nanoparticles; Anti-Photodegradation

期刊名称： INDUSTRIAL CROPS AND PRODUCTS

ISSN： 0926-6690

年卷期： 2020 年 152 卷

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： Polyethylene glycol (PEG) was introduced into carboxymethyl cellulose (CMC) to form hydrophilic chain of PEG-CMC. Avermectin (Avm) was grafted on the long chain of PEG-CMC by use of N, N-dicyclohexylcarbodiimide (DCC) as the dehydrant and 4-dimethylaminopyridine (DMAP) as the catalyst to form the amphiphilic molecule. Then the avermectin nanoparticles was prepared with esterase-responsive sustained release successfully through self-assembly. The size of nanoparticles was less than 400 nm. Avermectin loading was 8% and the degradation rate was less than 50 % under the xenon arc lamp for 72 h. Compared with avermectin technical, it showed an obvious anti-photodegradation advantage. Compared with commercially available water-dispersible granules (WDG), the avermectin nanoparticles had a smaller contact angle on the cucumber leaf surface and there was a significant difference. The toxicity test showed that the nanoparticles have a certain insecticidal effect on the larva of Hyphantria cunea and the sensitivity increased gradually over time.

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