数字农科院2.0

Characterization Of Diketopiperazine Heterodimers As Potential Chemical Markers For Discrimination Of Two Dominant Black Aspergilli, Aspergillus Niger And Aspergillus Tubingensis

文献类型： 外文期刊

作者： Xu, C; Xu, K; Yuan, XL; Ren, GW; Wang, XQ; Li, W; Deng, N; Wang, XF; Zhang, P

作者机构：

关键词： Aspergillus Tubingensis Mosseray (Discellaceae); Black Aspergilla; Chemotaxonomy; Diketopiperazine Heterodimers; Asperazines; Antifungal Activity

期刊名称： PHYTOCHEMISTRY

ISSN： 0031-9422

年卷期： 2020 年 176 卷

页码：

收录情况： JCR（2021版）

摘要： Black aspergilli are distributed worldwide and represent one of the most prolific sources of metabolites with biomedical and agrochemical interests. However, due to their similar morphological characteristics and insufficient molecular identification, the taxonomic classification of black aspergilli remains ill-defined. The production of specialised metabolites is often unique for species among black aspergilli and could be used as diagnostic chemical markers for species identification. In this study, chemical investigation of Aspergillus tubingensis OUCMBIII 143291 led to the discovery of the diagnostic chemical marker asperazine, a complex diketopiperazine heterodimer, as well as two previously undescribed analogues, asperazine B and C. In addition, an undescribed 2-benzylpyridin-4(1H)-one-containing amide, pestalamide D, along with four known related metabolites were isolated. Their chemical structures, including their absolute configurations, were established on the basis of comprehensive spectral analysis and chiral HPLC analysis of the acidic hydrolysates. Asperazines B and C can serve as potential chemical markers for distinguishing A. tubingensis from A. niger, two representative species of black aspergilli that are usually incorrectly identified. Moreover, the isolated compounds were evaluated for their antifungal activity against eight phytopathogenic fungi including Alternaria alternata, A. brassicae, Botrytis cinerea, Colletotrichum lagenarium, Fusarium oxysporum, Gaeumannomyces graminis, Penicillium digitatum, and Valsa mali. Pestalamide D exhibited significant activities against B. cinerea, C. lagenanum, and V. mali, with MIC values of 4, 8, and 8 mu g/mL, respectively, compared with the positive controls carbendazim (MICs = 8, 4, and 4 mu g/mL) and prochloraz (MICs = 8, 8, and 4 mu g/mL). The results of this study reveal two additional chemical markers and provide a powerful tool for the rapid identification of black aspergilli.

分类号：

  • 相关文献

[1]Halorubrum salipaludis sp. nov., isolated from the saline–alkaline soil. Gong Q., Zhao P., Miao S., Yi K., Ma C., Zhang G.. 2022

[2]Isolation, Identification, And Biocontrol Of A.ntagonistic Bacterium Against Botrytis C inerea After Tomato Harvest. Shi, Jun-Feng,Shi, Jun-Feng,Sun, Chang-Qing. 2017

[3]Synthesis, Crystal Structure And Bioactivities Of N-(5-(4-Chlorobenzyl)-1,3,5-Triazinan-2-Ylidene)Nitramide. Qin, Yao-Guo,Qin, Yao-Guo,Fan, Jia,Yang, Zhao-Kai,Jiang, Xin,Yang, Xin-Ling,Chen, Ju-Lian. 2020

[4]Stilbene Derivatives From Photorhabdus Temperata S.n259 And Their Antifungal A ctivities Against Phytopathogenic Fungi. Shi, DS, An, R, Zhang, WB, Zhang, GL, Yu, ZG. 2017

[5]Antifungal Prenylated Diphenyl Ethers From A.rthrinium Arundinis, An Endophytic F ungus Isolated From The Leaves Of Tobacco (Nicotiana Tabacum L.). Zhang, P, Li, X, Yuan, XL, Du, YM, Wang, BG, Zhang, ZF. 2018

[6]In Vitro And In Vivo A.ctivities Of Eugenol Against T obacco Black Shank Caused By Phytophthora Nicotianae. Jing, C, Gou, JL, Han, XB, Wu, Q, Zhang, CS. 2017

[7]Streptomyces Amphotericinicus Sp Nov., An A.mphotericinproducing Actinomycete Isolated From T he Head Of An Ant (Camponotus Japonicus Mayr). Cao, TT, Mu, S, Lu, C, Zhao, SS, Li, DM, Yan, K, Xiang, WS, Liu, CX. 2017

[8]Anti-Phytopathogenic And Cytotoxic Activities Of C.rude Extracts And Secondary M etabolites Of Marine-Derived Fungi. Zhao, DL, Wang, D, Tian, XY, Cao, F, Li, YQ, Zhang, CS. 2018

[9]Streptomyces Gamaensis Sp Nov., A N.ovel Actinomycete With Antifungal A ctivity Isolated From Soil In Gama, Chad. Zhao, SS, Ye, L, Liu, CX, Abagana, AY, Zheng, WW, Sun, PY, Li, JS, Xiang, WS, Wang, XJ. 2017

[10]Micromonospora Parathelypteridis Sp Nov., An E.ndophytic Actinomycete With Antifungal A ctivity Isolated From The Root Of Parathelypteris Beddomei (Bak.) Ching. Yan, Kai,Xiang, Wensheng,Zhao, Junwei,Zheng, Weiwei,Zhao, Shanshan,Cao, Tingting,Xiang, Wensheng,Liu, Chongxi,Wang, Xiangjing,Ma, Zhaoxu. 2017

[11]Identification and Predictions Regarding the Biosynthesis Pathway of Polyene Macrolides Produced by Streptomyces roseoflavus Men-myco-93-63. Han Xing,Wang Jiao,Liu Lianna,Shen Fengying,Meng Qingfang,Li Xing,Li Yaning,Liua Daqun. 2021

[12]In Vitro And In Vivo Antifungal Activity And Preliminary Mechanism Of Cembratrien-Diols Against Botrytis Cinerea. Yang, Q, Wang, J, Zhang, P, Xie, SN, Yuan, XL, Hou, XD, Yan, N, Fang, YD, Du, YM. 2020

[13]Novel Trifluoromethylpyrazole Acyl Thiourea Derivatives: S.ynthesis, Antifungal Activity And D ocking Study. Wang, H, Zhai, ZW, Shi, YX, Tan, CX, Weng, JQ, Han, L, Li, BJ, Liu, XH. 2019

[14]Thiophenes From Echinops Grijsii As A. Preliminary Approach To C ontrol Disease Complex Of Root-Knot Nematodes And Soil-Borne Fungi: Isolation, Activities, And Structure-Nonphototoxic Activity Relationship Analysis. Zhang, Lan,Wu, Haibo,Mao, Liangang,Jiang, Hongyun,Liu, Tingting,Zhang, Yanning. 2019

[15]The Antifungal Action Mode Of T.he Rice Endophyte Streptomyces H ygroscopicus Osish-2 As A Potential Biocontrol Agent Against The Rice Blast Pathogen. Zhou, Guoying,Franco, Christopher M. M.,Zhou, Qian,Liu, Ying,Wang, Xiang,Bu, Zhigang,Gao, Yan,Zeng, Jiarui,Hu, Xiaochun,Zhu, Yonghua,Liu, Xuanming,Shi, Liming,Cao, Lidan,Xu, Ting,Yang, Yuanzhu. 2019

[16]Insecticidal, Cytotoxic And Anti-Phytopathogenic Fungal Activities Of Chemical Constituents From The Aerial Parts Of Ferula Sinkiangensis. Liu, TT, Wang, LP, Zhang, L, Jiang, HY, Zhang, YN, Mao, LG. 2020

[17]Antifungal Activity Of Epsilon-Poly-L-Lysine On T.richothecium Roseum In Vitro A nd Its Mechanisms. Wei, ML, Ge, YH, Li, CY, Chen, YR, Wang, WH, Duan, B, Li, X. 2018

[18]Preparation, Characterization, And Evaluation Of A.zoxystrobin Nanosuspension Produced By W et Media Milling. Yao, JW, Cui, B, Zhao, X, Wang, Y, Zeng, ZH, Sun, CJ, Yang, DS, Liu, GQ, Gao, JM, Cui, HX. 2018

[19]Characterization Of Sinomonas Gamaensis Sp. N.ov., A Novel Soil B acterium With Antifungal Activity Against Exserohilum Turcicum. Fu, YS, Yan, R, Liu, DL, Zhao, JW, Song, J, Wang, XJ, Cui, L, Zhang, J, Xiang, WS. 2019

[20]Prickly Ash Seed Kernel: A New Bio-Fumigation Material Against Tobacco Black Shank. Wang, YC, Liu, MH, Han, XB, Zheng, YF, Chao, JM, Zhang, CS. 2020

作者其他论文 更多>>