数字农科院2.0

Investigation And Comparison Of The Protective Activities Of Three Functional Proteins-Lactoferrin, Alpha-Lactalbumin, And Beta-Lactoglobulin-In Cerebral Ischemia Reperfusion Injury

文献类型： 外文期刊

作者： Li, HY; Li, P; Yang, HG; Yao, QQ; Huang, SN; Wang, JQ; Zheng, N

作者机构：

关键词： Lactoferrin; Alpha-Lactalbumin; Beta-Lactoglobulin; Cerebral Ischemia Reperfusion; Toll-Like Receptor 4

期刊名称： JOURNAL OF DAIRY SCIENCE

ISSN： 0022-0302

年卷期： 2020 年 103 卷 6 期

页码：

收录情况： JCR（2021版）

摘要： The objective of this study was to evaluate the protection conferred by lactoferrin, alpha-lactalbumin, and beta-lactoglobulin in cerebral ischemia reperfusion (I/R) injury. Rat pheochromocytoma (PC12) cells were used to construct an oxygen and glucose deprivation model in vitro, and ICR mice underwent carotid artery "ligationrelaxation" to construct a cerebral I/R injury model in vivo. The levels of toll-like receptor 4 (TLR4) and downstream factors including nuclear factor-kappa B, tumor necrosis factor-alpha, and IL-1 beta were measured. Metabonomics detection and data mining were conducted to identify the specific metabolic sponsor of the 3 proteins. The results showed that lactoferrin, alpha-lactalbumin, and beta-lactoglobulin protected neurons from cerebral I/R injury by increasing the level of bopindolol and subsequently inhibiting the TLR4-related pathway to different degrees; beta-lactoglobulin had the strongest activity of the 3 proteins. In summary, this study is the first to investigate and compare the protective effects of lactoferrin, alpha-lactalbumin, and beta-lactoglobulin in a cerebral stroke model. The results implicate TLR4 as a novel target of the 3 bioactive proteins to prevent cerebral I/R injury.

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