数字农科院2.0

Evolutionary Dynamics And Age-Dependent Pathogenesis Of Sub-Genotype Vi.2.1.1.2.2 Ppmv-1 In Pigeons

文献类型： 外文期刊

作者： Xie, P; Chen, LB; Zhang, YF; Lin, QY; Ding, C; Liao, M; Xu, CG; Xiang, B; Ren, T

作者机构：

关键词： Ppmv-1; Sub-Genotype Vi.2.1.1.2.2; Phylogenetic Tree; Age; Pigeon; Pathogenesis; Transmission

期刊名称： VIRUSES-BASEL

ISSN：

年卷期： 2020 年 12 卷 4 期

页码：

收录情况： JCR（2021版）

摘要： Pigeon paramyxovirus type 1 (PPMV-1) infection causes high morbidity in pigeons, resulting in a significant burden to the poultry industry. In this study, we isolated three PPMV-1 strains from diseased pigeons collected in Guangdong Province, South China, from June 2017 to April 2019. Genetic analysis revealed that these three PPMV-1 strains and most of the PPMV-1 strains isolated from China after 2011 were clustered into sub-genotype VI.2.1.1.2.2. Our Bayesian analysis revealed that the VI.2.1.1.2.2 viruses might have originated in Europe. Phylogeographic analyses revealed that East and South China might have played a key role in seeding the VI.2.1.1.2.2 PPMV-1 epidemic in China. To characterize the effect of age at infection on the outcome of PPMV-1 infection in pigeons, we investigated the pathogenesis and transmission of the pigeon/Guangdong/GZ08/2017 (GZ08) virus in 3-, 6-, and 12-week-old pigeons. Two of six 12-week-old pigeons inoculated with GZ08 survived, and all of the 3- and 6-week-pigeons inoculated with GZ08 died. Moreover, the GZ08 virus could be transmitted to 3-, 6-, and 12-week-old naive contact pigeons. The lethality of the GZ08 virus through contact with 3-, 6-, and 12-week-old pigeons was 100%, 66.7%, and 0%, respectively, suggesting that the transmissibility of the GZ08 virus was stronger in young pigeons. These findings demonstrated that East and South China was the epicenter for dissemination of VI.2.1.1.2.2 PPMV-1, and age at infection has an impact on the outcome of PPMV-1 infection in pigeons.

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