数字农科院2.0

Effects Of An Antler Velvet-Based Natural Compound On Osteoporosis In A Rodent Model

文献类型： 外文期刊

作者： Zhao, HP; Wang, XH; Wang, Z; Du, FZ; Li, HT; Li, CY

作者机构：

关键词： Calcined Oyster Shell; Deer Blood; Osteoporosis; Velvet Antler

期刊名称： ANIMAL PRODUCTION SCIENCE

ISSN： 1836-0939

年卷期： 2020 年 60 卷 10 期

页码：

收录情况： JCR（2021版）

摘要： Context Velvet antlers (VA) are claimed to have the effects on osteoporosis in traditional Chinese medicine. Aims So as to scientifically confirm this claim, a VA-based compound (VAC, the mixture of upper part of VA, deer blood, and calcined oyster shell powder in a ratio of 4 : 1 : 1) was produced and administered to osteoporotic model rats, with osteoporosis being induced by retinoic acid via gavage. Methods In total, 48 rats were used and divided into six groups (8/group). Concentrations of alkaline phosphatase and osteocalcin in the rat serum were measured, and bone ash weight, concentrations of calcium and phosphorus in rat femur were measured. Bone biomechanical test was performed using a computer-controlled three-point bending tester. Ratio of trabecular bone area to tissue area in a given view field of the femoral tissue section was histologically examined and calculated. Bone histomorphometry was measured using micro-CT. Key results No significant difference was found between the VAC-treated groups and the positive control (alendronate sodium) on the basis of the following tested parameters: (1) levels of alkaline phosphatase and osteocalcin in rat serum; (2) maximum load value (N) of femur and maximum compression force of lumbar vertebra; (3) concentrations of calcium and phosphorus in femur; (4) ratio of trabecular bone area to tissue area; and (5) bone histomorphometry. Conclusions Effects of VAC used in the present study on osteoporosis in the model rats were comparable to the alendronate sodium (western medicine for treating osteoporosis) on the basis of our selected parameters. Implications This compound has the potential to be developed as an effective traditional Chinese medicine for clinic use to treat osteoporosis.

分类号：

  • 相关文献

[1]Development Of Novel Est Microsatellite Markers For Genetic Diversity Analysis And Correlation Analysis Of Velvet Antler Growth Characteristics In Sika Deer. Jia, BY, Wang, GW, Zheng, JJ, Yang, WY, Chang, SZ, Zhang, JL, Liu, Y, Li, QN, Ge, CX, Chen, G, Liu, DD, Yang, FH. 2020

[2]Association Between Tea Consumption And O.steoporosis A Meta-Analysis. Li, Xinghui,Cui, Qiaoyun,Wang, Le,Zhang, Wenzheng,Sun, Kang,Lv, Qianru,Ma, Qingping,Sun, Kang. 2017

[3]Novel And Rapid Osteoporosis Model E.stablished In Zebrafish Using H igh Iron Stress. Zhang, WJ, Xu, JJ, Qiu, JH, Xing, CC, Li, XM, Leng, B, Su, Y, Lin, JM, Lin, JF, Mei, XQ, Huang, YQ, Pan, YT, Xue, Y. 2018

[4]POLR2A blocks osteoclastic bone resorption and protects against osteoporosis by interacting with CREB1. Chuxiao Liu,Yu Han,Xingyu Zhao,Bo Li,Liwen Xu,Dongsong Li,Guangyu Li. 2021

作者其他论文 更多>>