数字农科院2.0

Intercellular Transmission Of Seneca Valley Virus Mediated By Exosomes

文献类型： 外文期刊

作者： Xu, GW; Xu, SX; Shi, XJ; Shen, CC; Hao, JH; Yan, MH; Zhang, DJ; Zhu, ZX; Zhang, KS; Zheng, HX; Liu, XT

作者机构：

关键词： Exosomes; Infection; Seneca Valley Virus; Immune Escape; Intercellular Transmission

期刊名称： VETERINARY RESEARCH

ISSN： 0928-4249

年卷期： 2020 年 51 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Seneca Valley virus (SVV) is a non-encapsulated single-stranded positive-strand RNA virus whose transmission routes have not yet been fully elucidated. Exosomes have been implicated in the intercellular transport of a variety of materials, such as proteins, RNA, and liposomes. However, whether exosomes can mediate SVV intercellular transmission remains unknown. In this study, we extracted exosomes from SVV-infected IBRS-2 cells to investigate intercellular transmission. Our results suggest that the intercellular transmission of SVV is mediated by exosomes. The results of co-localization and RT-qPCR studies showed that exosomes harbor SVV and enable the virus to proliferate in both susceptible and non-susceptible cells. Furthermore, the replication of SVV was inhibited when IBRS-2 cells were treated with interfering RNA Rab27a and exosome inhibitor GW4869. Finally, neutralization experiments were performed to further verify whether the virus was encapsulated by the exosomes that mediated transmission between cells. It was found that exosome-mediated intercellular transmission was not blocked by SVV-specific neutralizing antibodies. This study reveals a new transmission route of SVV and provides clear evidence regarding the pathogenesis of SVV, information which can also be useful for identifying therapeutic interventions.

分类号：

  • 相关文献

[1]Seneca Valley Virus 3C Protease N.egatively Regulates The Type I Interferon Pathway By Acting As A Viral Deubiquitinase. Xue, Q, Liu, HS, Zhu, ZX, Yang, F, Xue, QH, Cai, XP, Liu, XT, Zheng, HX. 2018

[2]Emergence Of Novel Seneca Valley V.irus Strains In China, 2 017. Zhu, Z, Yang, F, Chen, P, Liu, H, Cao, W, Zhang, K, Liu, X, Zheng, H. 2017

[3]Foot-and-Mouth Disease Virus Capsid Protein VP1 Antagonizes TPL2-Mediated Activation of the IRF3/IFN-β Signaling Pathway to Facilitate the Virus Replication. Junhong Hao,Chaochao Shen,Nannan Wei,Minghao Yan,Xuegang Zhang,Guowei Xu,Dajun Zhang,Jing Hou,Weijun Cao,Ye Jin,Keshan Zhang,Haixue Zheng,Xiangtao Liu. 2021

[4]Foot-and-Mouth Disease Virus Structural Protein VP1 Destroys the Stability of the TPL2 Trimer by Degradation of TPL2 To Evade Host Antiviral Immunity. Keshan Zhang,Minghao Yan,Junhong Hao,Chaochao Shen,Zixiang Zhu,Dajun Zhang,Jing Hou,Guowei Xu,Dan Li,Haixue Zheng,Xiangtao Liu. 2021

[5]Global profiling of miRNA and protein expression patterns in rabbit peritoneal macrophages treated with exosomes derived from Taenia pisiformis cysticercus. Wang, Liqun,Liu, Tingli,Pu, Guiting,Chen, Guoliang,Li, Hong,Zhang, Shaohua,Li, Yanping,Luo, Xuenong. 2023

[6]Comparative Study of the Expression Profiles of miRNAs of Milk-Derived Exosomes of Yak and Jeryak. Wenwen Ren,Yongfeng Zhang,Renqing Dingkao,Chun Huang,Xiaoming Ma,Xiaoyun Wu,Yongfu La,Min Chu,Pengjia Bao,Xian Guo,Jie Pei,Ping Yan,Chunnian Liang. 2022

[7]Research Progress On The Composition A.nd Function Of Parasite-Derived E xosomes. Nawaz, M, Malik, MI, Hameed, M, Zhou, JL. 2019

[8]Exosomes-Mediated Transmission Of Foot-And-Mouth Disease V.irus In Vivo And I n Vitro. Zhang, KS,Xu, SX,Shi, XJ,Xu, GW,Shen, CC,Liu, XT,Zheng, HX. 2019

[9]Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration. Yan Zhang,Jiaqing Yan,Yanhong Liu,Zhenyu Chen,Xiheng Li,Liang Tang,Jiang Li,Mengna Duan,Guokun Zhang. 2021

[10]Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition. Yan Zhang,Yingjin Pan,Yanhong Liu,Xiheng Li,Liang Tang,Mengna Duan,Jiang Li,Guokun Zhang. 2021

[11]Exosomes Derived From Dendritic Cells Infected With Toxoplasma gondii Show Antitumoral Activity in a Mouse Model of Colorectal Cancer. Lu, Jinmiao,Wei, Nana,Zhu, Shilan,Chen, Xiaoyu,Gong, Haiyan,Mi, Rongsheng,Huang, Yan,Chen, Zhaoguo,Li, Guoqing. 2022

[12]Engineered antler stem cells derived exosomes potentiate anti-tumor efficacy of immune checkpoint inhibitor by reprogramming immunosuppressive tumor microenvironment. Yang, Min,Pu, Li,Yang, Shuiyue,Chen, Ze,Guo, Jia,Liu, Ying,Chang, Shuzhuo,Peng, Yinghua. 2024

[13]Multi-omics reveals aspirin eugenol ester alleviates neurological disease. Qi Tao,Zhen Dong Zhang,Xiao Rong Lu,Zhe Qin,Xi Wang Liu,Shi Hong Li,Li Xia Bai,Bo Wen Ge,Jian Yong Li,Ya Jun Yang. 2023

[14]Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system. Yingrui Li,Ze Chen,Jia Guo,Deshuang Meng,Xin Pang,Zepeng Sun,Li Pu,Shuiyue Yang,Min Yang,Yinghua Peng. 2024

[15]Repair of Mechanical Cartilage Damage Using Exosomes Derived from Deer Antler Stem Cells. Zhou, Jue,Zhao, Jianwei,Wang, Yimin,Jiang, Yidi,Li, Xunsheng,Wang, Datao,Yue, Zhigang,Lv, Jinpeng,Sun, Hongmei. 2024

[16]MicroRNA in the Exosomes Mediated by Resveratrol to Activate Neuronal Cells. Zhang Z.,Tao Q.,Bai L.,Qin Z.,Liu X.,Li S.,Yang Y.,Ge W.,Li J.. 2024

[17]Plant exosome-like nanovesicles derived from sesame leaves as carriers for luteolin delivery: Molecular docking, stability and bioactivity. Jiang, Dan,Li, Ziliang,Liu, Hongyan,Liu, Huihui,Xia, Xiaoyang,Xiang, Xia. 2024

[18]Milk-derived exosomes in the regulation of nutritional and immune functions. Yang, Hui,Wuren, Tana,Zhai, Bin-tao,Liu, Yang,Er, Demtu. 2024

[19]Untargeted metabolomics investigating porcine reproductive and respiratory syndrome virus biomarkers of serum-derived exosomes in piglets infected with PRRSV NADC30-like CHsx1401. Feng Cheng,Jia Li,Chunxiang Zhou,Lei Zhou,Ganqiu Lan,Jing Liang,Lixian Wang,Ligang Wang. 2025

[20]Exosomes Derived from Antler Mesenchymal Stem Cells Promote Wound Healing by miR-21-5p/STAT3 Axis. Meng, Deshuang,Li, Yingrui,Chen, Ze,Guo, Jia,Yang, Min,Peng, Yinghua. 2024

作者其他论文 更多>>