Angustoline Inhibited Esophageal Tumors Through Regulating Lkb1/Ampk/Elavl1/Lpact2 Pathway And Phospholipid Remodeling
文献类型: 外文期刊
作者: Li, HY; Zhang, C; Zhang, M; Yao, QQ; Yang, HG; Fan, LL; Zheng, N
作者机构:
关键词: Esophageal Cancer; Lkb1; Ampk; Elavl1; Lpcat2; Lipidomics
期刊名称: FRONTIERS IN ONCOLOGY
ISSN: 2234-943X
年卷期: 2020 年 10 卷
页码:
收录情况: JCR(2021版)
摘要: Esophageal cancer is a type of gastrointestinal carcinoma and is among the 10 most common causes of cancer death worldwide. However, the specific mechanism and the biomarkers in the proliferation and metastasis of esophageal tumors are still unclear. Therefore, the development of several natural products which could inhibit esophageal tumors deserve attention. In the present study, different sources of cancer cells were used to select the sensitive cell line (esophageal cancer cell KYSE450) and the proper dose of angustoline, which were utilized in the following cell viability, migration and invasion assays. Then the lipidomic detection of clinical samples (tissue and blood plasma) from esophageal cancer patients was performed, to screen out the specific phospholipid metabolites [PC (16:0/18:1) and LPC (16:0)]. Considering lysophosphatidylcholine acyltransferase 2 (LPCAT2) was tightly relative with phospholipids conversion, serine/threonine-protein kinase 11 (LKB1), 5 '-monophosphate (AMP)-activated protein kinase (AMPK) and embryonic lethal, and abnormal vision, drosophila-like 1 (ELAVL1) were investigated, to evaluate their expression levels in esophageal tumor tissue and KYSE450 cells. Additionally, KYSE450 tumor bearing mouse model was constructed, the role of angustoline in inhibiting esophageal tumors through regulating LKB1/AMPK/ELAVL1/LPCAT2 pathway was validated, and found that the conversion from LPC (16:0) to PC (16:0/18:1) was blocked by angustoline in some degree. The above results for the first time proved that angustoline suppressed esophageal tumors through activating LKB1/AMPK and inhibiting ELAVL1/LPCAT2, which consequently blocked phospholipid remodeling from LPC (16:0) to PC (16:0/18:1).
分类号:
- 相关文献
作者其他论文 更多>>
-
Transcriptome Analysis Of Ochratoxin A-Induced Apoptosis In Differentiated Caco-2 Cells
作者:Yang, X; Gao, YN; Yan, QY; Bao, XY; Zhao, SG; Wang, JQ; Zheng, N
关键词:Ochratoxin A; Differentiated Caco-2 Cells; Cell Apoptosis; Transcriptome Analysis
-
Modulation Activity Of Heat-Treated And Untreated Lactoferrin On The Tlr-4 Pathway In Anoxia Cell Model And Cerebral Ischemia Reperfusion Mouse Model
作者:Yang, HG; Li, HY; Li, P; Bao, XY; Huang, GX; Xing, L; Zheng, N; Wang, JQ
关键词:Heat Treatment; Lactoferrin; Anoxia And Reoxygenation; Cerebral Ischemic Reperfusion
-
Comparative Study On Chemical Composition, Polyphenols, Flavonoids, Carotenoids And Antioxidant Activities Of Various Cultivars Of Sweet Potato
作者:Kourouma, V; Mu, TH; Zhang, M; Sun, HN
关键词:Antioxidant Activities; Carotenoids; Chemical Composition; Flavonoids; Polyphenols; Sweet Potato
-
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism And Irf3 Activation To Eliminate Infection
作者:Xiao, J; Li, WY; Zheng, X; Qi, LL; Wang, H; Zhang, C; Wan, XP; Zheng, YX; Zhong, RY; Zhou, X; Lu, Y; Li, ZQ; Qiu, Y; Liu, C; Zhang, F; Zhang, YB; Xu, XY; Yang, ZZ; Chen, HL; Zhai, QW; Wei, B; Wang, HY
关键词:
-
Different Milk Replacers Alter Growth Performance And Rumen Bacterial Diversity Of Dairy Bull Calves
作者:Zhang, YD; Cheng, J; Zheng, N; Zhang, YQ; Jin, D
关键词:Bacterial Diversity; Bull Calf; Diet Composition; Growth Performance; Rumen
-
Mads78 And Mads79 Are Essential Regulators Of Early Seed Development In Rice
作者:Paul, P; Dhatt, BK; Miller, M; Folsom, JJ; Wang, Z; Krassovskaya, I; Liu, K; Sandhu, J; Yu, HH; Zhang, C; Obata, T; Staswick, P; Walia, H
关键词:
-
Genetic Diversity And Population Structure Ofcannabisbased On The Genome-Wide Development Of Simple Sequence Repeat Markers
作者:Zhang, JJ; Yan, JT; Huang, SQ; Pan, G; Chang, L; Li, JJ; Zhang, C; Tang, HJ; Chen, AG; Peng, DX; Biswas, A; Zhang, CP; Zhao, LN; Li, DF
关键词:Cannabis; Genetic Diversity; Population Structure; Simple Sequence Repeat; Cluster Analysis