数字农科院2.0

A Novel Mechanism Of Bta-Mir-210 In Bovine Early Intramuscular Adipogenesis

文献类型： 外文期刊

作者： Ren, L; Li, Q; Hu, X; Yang, QY; Du, M; Xing, YS; Wang, YH; Li, JY; Zhang, LP

作者机构：

关键词： Bta-Mir-210; Bovine; Progenitor Cells; Intramuscular Adipogenesis; Wisp2

期刊名称： GENES

ISSN：

年卷期： 2020 年 11 卷 6 期

页码：

收录情况： JCR（2021版）

摘要： Intramuscular fat (IMF) is one of the major factors determining beef quality. IMF formation is influenced by multiple conditions including genetic background, age and nutrition. In our previous investigation, bta-miR-210 was found to be increased during adipogenesis using miRNA-seq. In this study, we validated the upregulation of bta-miR-210 in platelet-derived growth factor receptor alpha positive (PDGFR alpha(+)) progenitor cells during adipogenic differentiation in vitro. To investigate its role in adipogenesis, bta-miR-210 mimics were introduced into progenitor cells, which resulted in enhanced intracellular lipid accumulation. Accordingly, the expression of adipocyte-specific genes significantly increased in the bta-miR-210 mimic group compared to that in the negative control group (p< 0.01). Dual-luciferase reporter assays revealed thatWISP2is a target of bta-miR-210.WISP2knockdown enhanced adipogenesis. In conclusion, bta-miR-210 positively regulates the adipogenesis of PDGFR alpha(+)cells derived from bovine fetal muscle by targetingWISP2.

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