数字农科院2.0

Microbiota From Alginate Oligosaccharide-Dosed Mice Successfully Mitigated Small Intestinal Mucositis

文献类型： 外文期刊

作者： Zhang, PF; Liu, J; Xiong, BH; Zhang, C; Kang, BN; Gao, YS; Li, ZK; Ge, W; Cheng, SF; Hao, YN; Shen, W; Yu, S; Chen, L; Tang, XF; Zhao, Y; Zhang, HF

作者机构：

关键词： Fecal Microbiota Transplantation; Alginate Oligosaccharides; Mucositis; Busulfan; Rescue; Metabolome; Correlation

期刊名称： MICROBIOME

ISSN： 2049-2618

年卷期： 2020 年 8 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Background The increasing incidence of cancer and intestinal mucositis induced by chemotherapeutics are causing worldwide concern. Many approaches such as fecal microbiota transplantation (FMT) have been used to minimize mucositis. However, it is still unknown whether FMT from a donor with beneficial gut microbiota results in more effective intestinal function in the recipient. Recently, we found that alginate oligosaccharides (AOS) benefit murine gut microbiota through increasing "beneficial" microbes to rescue busulfan induced mucositis. Results In the current investigation, FMT from AOS-dosed mice improved small intestine function over FMT from control mice through the recovery of gene expression and an increase in the levels of cell junction proteins. FMT from AOS-dosed mice showed superior benefits over FMT from control mice on recipient gut microbiotas through an increase in "beneficial" microbes such asLeuconostocaceaeand recovery in blood metabolome. Furthermore, the correlation of gut microbiota and blood metabolites suggested that the "beneficial" microbeLactobacillaleshelped with the recovery of blood metabolites, while the "harmful" microbeMycoplasmatalesdid not. Conclusion The data confirm our hypothesis that FMT from a donor with superior microbes leads to a more profound recovery of small intestinal function. We propose that gut microbiota from naturally produced AOS-treated donor may be used to prevent small intestinal mucositis induced by chemotherapeutics or other factors in recipients.

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