Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens
文献类型: 外文期刊
作者: Lu Tong;Chen Hua-lan;Mao Sheng-gang;Li Yan-bing;Tian Guo-bin;Wu Jiao-jiao;Ma Shu-jie;Chen Xiao-han;Bao Hong-mei;Liu Jing-li;Shi Jian-zhong;Chen Pu-cheng;Zeng Xian-ying;Hu Jing-lei;Deng Guo-hua;Jiang Yong-ping;Guo Xing-fu;Pan Shu-xin;Liu Yan-jing
作者机构:
关键词: Avian Influenza; H5/H7 Trivalent Vaccine; Re-11; Re-12 And H7-Re2 Strains; Protective Efficacy
期刊名称: Journal of Integrative Agriculture
ISSN: 2095-3119
年卷期: 2020 年 19 卷 9 期
页码:
收录情况: JCR(2021版) ; CSCD(2020-2021年度) ; 农林核心(2020版) ; 科技核心(2020版)
摘要: We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/ Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50-60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.
分类号:
- 相关文献
作者其他论文 更多>>
-
The pig pangenome provides insights into the roles of coding structural variations in genetic diversity and adaptation
作者:Zhengcao Li;Xiaohong Liu;Chen Wang;Zhenyang Li;Bo Jiang;Ruifeng Zhang;Lu Tong;Youping Qu;Sheng He;Haifan Chen;Yafei Mao;Qingnan Li;Torsten Pook;Yu Wu;Yanjun Zan;Hui Zhang;Lu Li;Keying Wen;Yaosheng Chen
关键词:
-
Emergence of H5N1 highly pathogenic avian influenza in Democratic People’s Republic of Korea
作者:LIU Li-ling;YANG Huan-liang;GUO Fu-sheng;WANG Xiu-rong;DENG Guo-hua;SHI Jian-zhong;TIAN Guo-bin;ZENG Xian-ying
关键词:
-
Analysis of glucosinolate content, composition and expression level of biosynthesis pathway genes in different chinese kale varieties
作者:Lu Tong;Shanhan Cheng;Honghao Lv;Chengzhi Zhao;Jie Zhu;Pingwu Liu;Zhiwei Wang;Limei Yang;Yangyong Zhang
关键词:Chinese kale;Gene expression;Glucosinolate content and component;HPLC-MS