数字农科院2.0

Comparative Dna Methylome Analysis Of Estrus Ewes Reveals The Complex Regulatory Pathways Of Sheep Fecundity

文献类型： 外文期刊

作者： Miao, XY; Luo, QM; Xie, LL; Zhao, HJ; Qin, XY

作者机构：

关键词： Sheep; Epigenetics; Ovary; Methylation; Fecundity

期刊名称： REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY

ISSN：

年卷期： 2020 年 18 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Background/aims Sheep are important livestock with variant ovulation rate and fertility. Dorset sheep is a typical breed with low prolificacy, whereas Small Tail Han sheep with FecB mutation (HanBB) have hyperprolificacy. Our previous studies have revealed the gene expression difference between the ovaries from Dorset and HanBB sheep contributes to the difference of fecundity, however, what leads to these gene expression difference remains unclear. DNA methylation, an important epigenetic process, plays a crucial role in gene expression regulation. Methods In the present study, we constructed a methylated DNA immunoprecipitation combined with high throughput sequencing (MeDIP-seq) strategy to investigate the differentially methylated genes between the Dorset and HanBB ovaries. Results Our findings suggest the genes involved in immune response, branched-chain amino acid metabolism, cell growth and cell junction were differentially methylated in or around the gene body regions. Conclusions These findings provide prospective insights on the epigenetic basis of sheep fecundity.

分类号：

  • 相关文献

[1]Identification And Expression Patterns Of T.hree Vitellogenin Genes And T heir Roles In Reproduction Of The Alligatorweed Flea Beetle Agasicles Hygrophila (Coleoptera: Chrysomelidae). Zhao, Meiting,Guo, Jianying,Jin, Jisu,Liu, Yiran,Zhang, Hong,Zhou, Zhongshi,Wang, Yao. 2019

[2]Identification Of Ovarian Circular Rnas And Differential Expression Analysis Between Meishan And Large White Pigs. Liang, GM, Yan, JY, Guo, J, Tang, ZL. 2020

[3]An Integrated Analysis Of Mirnas A.nd Methylated Genes Encoding M rnas And Lncrnas In Sheep Breeds With Different Fecundity. Miao, XY, Luo, QM, Zhao, HJ, Qin, XY. 2017

[4]Expression And Functional Analysis Of T.he Bcl2-Associated Agonist Of C ell Death (Bad) Gene In The Sheep Ovary During The Reproductive Cycle. Cao, XH, Wang, XY, Lu, LL, Li, XY, Di, R, He, XY, Hu, WP, Zeng, XY, Liu, QY, Chu, MX. 2018

[5]Ovarian Transcriptomic Analysis Reveals The A.lternative Splicing Events Associated W ith Fecundity In Different Sheep Breeds. Miao, XY, Luo, QM, Zhao, HJ, Qin, XY. 2018

[6]Comparative Transcriptomics Reveal Key Sheep (.Ovis Aries) Hypothalamus Lncrnas T hat Affect Reproduction. Zhang, ZB, Tang, JS, Di, R, Liu, QY, Wang, XY, Gan, SQ, Zhang, XS, Zhang, JL, Hu, WP, Chu, MX. 2019

[7]赖氨酸对绵羊GHR基因表达的影响(英文). 李建升,程胜利,韩向敏,冯瑞林,岳耀敬,杨博辉,刘建斌. 2009

[8]基于ssRNA-seq研究差异基因、NATs对藏羊高原低氧适应的调控. 岳耀敬,冯瑞林,王天翔,郭婷婷,李桂英,孙晓萍,刘建斌,李文辉,牛春娥,郭健,李范文,杨博辉. 2015

[9]Transcriptome And Dna Methylation Analyses Of The Molecular Mechanisms Underlying With Longissimus Dorsi Muscles At Different Stages Of Development In The Polled Yak. Fu, Donghai,Lei, Qinhui,Guo, Xian,Jia, Congjun,Chu, Min,Ding, Xuezhi,Ma, Xiaoming,Liang, Chunnian,Bao, Pengjia,Wu, Xiaoyun,Pei, Jie,Jia, Congjun,Ding, Xuezhi,Pei, Jie,Guo, Xian,Ma, Xiaoming,Chu, Min,Lei, Qinhui,Fu, Donghai,Wu, Xiaoyun,Yan, Ping,Bao, Pengjia. 2019

[10]Identification And Function Analysis Of D.rought-Specific Small Rnas In G ossypium Hirsutum L.. Lu, XK, Yin, ZJ, Wang, JJ, Chen, XG, Wang, DL, Wang, S, Guo, LX, Fan, WL, Chen, C, Wang, XG, Cui, RF, Zhang, BL, Han, MG, Yang, XM, Ye, WW. 2019

[11]Comparison Of Six Methylation Methods F.or Fatty Acid Determination I n Yak Bone Using Gas Chromatography. Jia, W, Liu, WY, Mi, S, Zhang, CH, Li, X, Wu, T, Yu, QL. 2017

[12]A 5-Methylcytosine Site Of Growth D.ifferentiation Factor 9 (Gdf9) G ene Affects Its Tissue-Specific Expression In Sheep. Pan, ZY, Wang, XY, Di, R, Liu, QY, Hu, WP, Cao, XH, Guo, XF, He, XY, Lv, SJ, Li, FK, Wang, H, Chu, MX. 2018

[13]Vitamin B and Vitamin C affect DNA methylation and amino acid metabolism in Mycobacterium bovis BCG. Song, Ningning,Zhu, Yongqiang,Cui, Yingying,Zheng, Huajun,Lv, Mingyue,Tang, Yiyi,Cui, Ziyin,Dang, Guanghui,Liu, Siguo. 2020

[14]Simultaneous Determination Of Ethylenebisdithiocarbamate (Ebdc) A.nd Propylenebisdithiocarbamate (Pbdc) Fungicides I n Vegetables, Fruits, And Mushrooms By Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry. Li, J, Dong, C, Yang, Q, An, WJ, Zheng, ZT, Jiao, BN. 2019

[15]Comparative Proteomic Profiling Reveals Molecular C.haracteristics Associated With Oogenesis A nd Oocyte Maturation During Ovarian Development Of Bactrocera Dorsalis (Hendel). Li, Ran,Zhang, Meng-Yi,Liu, Yu-Wei,Zhang, Zheng,Smagghe, Guy,Wang, Jin-Jun,Wei, Dong,Wei, Dong,Wei, Dong,Li, Ran,Zhang, Meng-Yi,Wang, Jin-Jun,Smagghe, Guy,Liu, Yu-Wei,Zhang, Zheng,Smagghe, Guy. 2017

[16]Gene Expression Profiling Of Ovary I.dentified Eggshell Proteins Regulated B y 20-Hydroxyecdysone In Bactrocera Dorsalis. Liu, Yu-Wei,Smagghe, Guy,Smagghe, Guy,Smagghe, Guy,Wang, Jin-Jun,Wang, Jin-Jun,Zhang, Ying-Xin,Wei, Dong,Liu, Yu-Wei,Zhang, Ying-Xin,Wei, Dong,Li, Wei-Jun,Wei, Dong,Li, Wei-Jun,Chen, Zhi-Xian,Chen, Zhi-Xian. 2019

[17]Quantitative Proteomic Analysis Of Ovaries From Nosema Bombycis-Infected Silkworm (Bombyx Mori). Shen, Zhongyuan,Shen, Zhongyuan,Zhang, Yiling,Zhang, Yiling,Tang, Xudong,Zhou, Yumin,Liu, Ruting,Tang, Xudong. 2020

[18]Expression And Localization Of Piwi Proteins In Testis And Ovary Of Domestic Sheep. Li, CY, Liu, QY, Wang, XY, Hu, WP, Han, DP, Mwacharo, JM, Wei, CH, Chu, MX, Di, R. 2020

[19]Chlorothalonil Inhibits Mouse Ovarian Development T.hrough Endocrine Disruption. Hao, Y, Zhang, HF, Zhang, PF, Yu, S, Ma, DX, Li, L, Feng, YN, Min, LJ, Shen, W, Zhao, Y. 2019

[20]The Vitellogenin Receptor Has An E.ssential Role In Vertical T ransmission Of Rice Stripe Virus During Oogenesis In The Small Brown Plant Hopper. Li, Fei,Lin, Kejian,He, Kang,He, Kang,Ding, Simin,He, Kang,Wang, Guirong. 2019

作者其他论文 更多>>