数字农科院2.0

Fiber-1, Not Fiber-2, Directly Mediates The Infection Of The Pathogenic Serotype 4 Fowl Adenovirus Via Its Shaft And Knob Domains

文献类型： 外文期刊

作者： Wang, WK; Liu, Q; Li, TF; Geng, TY; Chen, HJ; Xie, Q; Shao, HX; Wan, ZM; Qin, AJ; Ye, JQ

作者机构：

关键词： Fadv-4; Fiber-1; Infection; Knob Domain; Vaccine; Hepatitis-Hydropericardium Syndrome

期刊名称： JOURNAL OF VIROLOGY

ISSN： 0022-538X

年卷期： 2020 年 94 卷 17 期

页码：

收录情况： JCR（2021版）

摘要： Recently, the disease of hepatitis-hydropericardium syndrome (HPS) caused by serotype 4 fowl adenovirus (FAdV-4) has spread widely and resulted in huge economic losses to the poultry industry. Although the genome of FAdV-4 has two fiber genes (fiber-1 and fiber-2), the exact role of the genes in the infection of FAdV-4 is barely known. In this study, through superinfection resistance analysis and an interfering assay, we found that fiber-1, but not fiber-2, was the key factor for di-rectly triggering the infection of FAdV-4. The truncation analysis further revealed that both of the shaft and knob domains of fiber-1 were required for the infection. Moreover, the sera against the knob domain were able to block FAdV-4 infection, and the knob-containing fusion protein provided efficient protection against the le-thal challenge of FAdV-4 in chickens. All the data demonstrated the significant roles of fiber-1 and its knob domain in directly mediating the infection of FAdV-4, which established a foundation for identifying the receptor of FAdV-4 and developing effi-cient vaccines against FAdV-4. IMPORTANCE Among 12 serotypes of fowl adenovirus (FAdV), FAdV-1, FAdV-4, and FAdV-10 all carry two fiber genes (i.e., fiber-1 and fiber-2), whereas other serotypes have only one. As important viral surface proteins, the fibers play vital roles in the infection and pathogenesis of FAdV. However, the importance of the fibers to the infection and pathogenesis of FAdV may be different from each other. Recent stud-ies reveal that fiber-2 is identified as a determinant of virulence, but which fiber trig-gers the infection of FAdV-4 remains unknown. In this study, fiber-1 was identified as a key factor for directly mediating the infection of FAdV-4 through its shaft and knob domains, whereas fiber-2 did not play a role in triggering FAdV-4 infection. The results suggest that fiber-1 and its knob domain may serve as a target for iden-tifying the receptor of FAdV-4 and developing efficient drugs or vaccines against FAdV-4.

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