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A Single Dose Of An Adenovirus-Vectored Vaccine Provides Protection Against Sars-Cov-2 Challenge

文献类型: 外文期刊

作者: 钟功勋;;帅磊;;温志远;;刘任强;;王翀;;王金良;;步志高

作者机构:

期刊名称: NATURE COMMUNICATIONS

ISSN: 2041-1723

年卷期: 2020 年 11 卷 1 期

页码:

收录情况: JCR(2021版)

摘要: The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we find that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protect mice completely against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protects ferrets from wild-type SARS-CoV-2 infection in the upper respiratory tract. This study suggests that the mucosal vaccination may provide a desirable protective efficacy and this delivery mode is worth further investigation in human clinical trials.

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